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Posted by Chrom Tech on 7th Oct 2025

Syringe Filters for HPLC Sample Preparation: A Guide to Choosing the Right Filter for Consistent and Accurate Results

How to Choose the Right Syringe Filter for HPLC Sample Preparation Sample preparation is a critical step in high-performance liquid chromatography (HPLC). One of the most common techniques to ensure r …

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Posted by Chrom Tech on 7th Oct 2025

Pore Size vs. Particle Size in HPLC Columns

When selecting an HPLC column, it's important to understand the key attributes that affect chromatography. Chemical properties, such as stationary phase type and pore size, influence sensitivity an …

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Posted by Chrom Tech on 6th Oct 2025

Acetonitrile vs. Methanol for Reverse Phase Chromatography

Comparing Acetonitrile vs Methanol in Reversed-Phase Chromatography Acetonitrile (ACN) and Methanol (MeOH) are the two most widely used organic modifiers in reversed-phase liquid chromatography. Each …

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27th Jun 2025

Should I Use a Guard Column

HPLC Columns The column is one of the most crucial components in an LC system, as it is where analytes are separated from a mixture for both qualitative and quantitative analysis. While HPLC colu …

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27th Jun 2025

How To Maximize HPLC Column Lifetime

All chromatographic columns experience wear over time. Key factors that contribute to the degradation of HPLC columns include sample injections, as sample matrices may contain residual proteins, lipid …

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29th Jan 2025

Revolutionizing UHPLC Connections: Introducing MarvelXACT by IDEX

Reliable HPLC fittings are essential for achieving accurate and consistent results in UHPLC (Ultra-High Performance Liquid Chromatography) applications. Improper fittings can result in leaks, l …

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29th Jan 2025

EHS Compliance: Safely Manage HPLC Solvent Waste

Many solvents and even samples used in high-performance liquid chromatography (HPLC) can be hazardous and/or flammable. As a result, it’s crucial to minimize health and safety risks to laboratory pers …

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16th Jan 2025

New and Dangerous Synthetic Opioids

Are New Synthetic Opioids Increasing Risks?Synthetic opioids are widely utilized in medical environments for their analgesic properties, offering relief to those experiencing severe pain. However, the …

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9th Jan 2025

What LC Column Should I Use for EtG and EtS Detection?

Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are metabolites produced by the liver following ethanol consumption. These substances can be identified in urine within 2-80 hours after alcohol intake. …

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9th Jan 2025

Using 96 Well Plates In High Throughput Laboratories

For high-throughput labs, using 96 well plates instead of autosampler vials offers considerable advantages, particularly in terms of automation. While not all steps in the process can be ful …

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6th Jan 2025

How do Stainless-Steel Fittings Differ from Polymer-Based Fittings?

Stainless-steel and polymer-based fittings are both commonly used in HPLC, each with its own set of advantages and disadvantages. The choice between them depends on the specific application and method …

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20th Dec 2024

How to Connect a Syringe to HPLC Tubing

Connecting a syringe to your LC pump for tasks like priming the system (and other applications) is a common need. We've seen various inventive solutions in laboratories where people have connected the …

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20th Dec 2024

An Essential Guide to HPLC Fittings for Your Laboratory

An Introduction to HPLC FittingsFittings are essential whenever tubing needs to be attached, adapted, or adjusted within the system, making secure connections crucial for successful chromatography. In …

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19th Dec 2024

A Sneak Peak into the Largest HPLC Industry in the World - Biotechnology Applications

Biotechnology is a vast field and one of the largest industries globally, playing a crucial role in food and agriculture, medicine, genetic research, and beyond. The ability to analyze compounds and d …

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4th Dec 2024

Which 96-Well Plate Should I Use for LCMS?

Choosing the right 96-well plate depends on several factors, including whether it is rimmed or non-rimmed, its sample recovery capabilities, and the potential for sample binding.Rimmed vs. Non-Rimmed …

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4th Dec 2024

To Cut or Not-to-Cut

To Cut or Not to Cut: Is Paying Extra for Pre-Cut Stainless Steel Tubing Worth It?When setting up your HPLC system, it's crucial that the ends of your tubing are flat and free of burrs. This ensures t …

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3rd Dec 2024

Reverse-Phase Liquid Chromatography vs. Hydrophilic Interaction Liquid Chromatography

Liquid chromatography can be performed using various techniques, including reverse-phase and hydrophilic interaction liquid chromatography (HILIC). This method of chromatography involves an HPLC pump …

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3rd Dec 2024

Pesticide and Mycotoxin Analysis in Cannabis Brownies

Accurate and dependable results for pesticide and mycotoxin analysis are essential to ensure the safety of individuals consuming cannabis-derived items, such as cannabis brownies and various edibles. …

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10th Jun 2024

Five Ways to Reduce Costs in Your Chromatography Workflow

How You Can Save Money in Your Chromatography Laboratory Chromatography is a powerful analytical technique, but costs can add up quickly. Lab managers are regularly challenged to keep costs to a min …

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31st May 2024

How to Cut HPLC Tubing: Your Guide to Peak Performance

High-pressure liquid chromatography (HPLC) is a powerful analytical technique, but results can depend greatly on seemingly minor details, such as the tubing used throughout the system. In this arti …

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4th Jan 2024

Revolutionizing Your Chromatography | The Power of Poroshell and more

Are you frustrated with increasing backpressures from your current HPLC column? Do you wish you could achieve UHPLC results with HPLC instrumentation? Choosing the proper tools for success is importan …

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3rd Jan 2024

Unlocking the Benefits of Agilent Bond Elut HLB SPE

Discover how Agilent Bond Elut HLB SPE products can revolutionize your sample preparation process and provide optimal results.Understanding the Importance of Sample Preparation Sample prepar …

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