Thermo Scientific

Thermo Fisher Scientific HPLC and UHPLC Columns

Thermo Fisher Scientific HPLC and UHPLC columns deliver exceptional analytical precision, robust stability, and consistent performance across a broad range of separation modes. Designed for demanding pharmaceutical, environmental, and life-science workflows, these columns support accurate quantitation and reproducibility on any major LC platform.

The Accucore™ series features solid-core particle technology engineered for high-speed, high-resolution separations with low backpressure—ideal for modern UHPLC and fast HPLC methods. Hypersil GOLD™ columns provide industry-leading peak symmetry, efficiency, and batch-to-batch consistency across a wide pH range, making them a trusted choice for method development and routine analysis.

Chrom Tech supplies the full portfolio of Thermo Fisher Scientific HPLC and UHPLC columns, helping analytical labs achieve uncompromising performance and reproducibility from small-molecule separations to peptide and biomolecule workflows. For personalized recommendations, contact Chrom Tech.

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Key Definitions ▸
Solid-Core Particle Technology
A particle architecture featuring a solid core surrounded by a porous outer layer. Used in Accucore columns to increase efficiency, reduce band broadening, and deliver UHPLC-like performance at lower backpressure.
Fully Porous Silica Particles
Classic chromatographic media used in Hypersil GOLD columns, offering high efficiency, exceptional peak symmetry, and robust performance across a wide pH range and diverse analyte classes.
Peak Symmetry
A measure of chromatographic peak shape. Columns with high symmetry, such as Hypersil GOLD, improve quantitation accuracy and minimize tailing—critical for LC-MS and trace-level analyses.
UHPLC Compatibility
The ability of a column to operate under very high pressures (often >600 bar). Accucore and select Hypersil GOLD formats support rapid gradients and high-throughput separations without sacrificing efficiency.
Method Development Flexibility
The ability to adjust selectivity, pH, and retention without switching column families. Hypersil GOLD phases are engineered to deliver predictable, reproducible performance across varied mobile phase conditions—ideal for establishing robust analytical methods.
Frequently Asked Questions ▸
What are the main differences between Accucore and Hypersil GOLD columns?
Accucore columns use solid-core particles to deliver high speed, high resolution, and reduced backpressure—ideal for UHPLC and fast-paced LC-MS workflows. Hypersil GOLD columns use fully porous silica optimized for exceptional peak symmetry, broad pH stability, and robust method development across diverse analyte classes.
Are Thermo Fisher HPLC columns compatible with other LC systems?
Yes. Thermo Fisher Scientific columns are universally compatible with all standard HPLC and UHPLC systems, allowing seamless integration into workflows across manufacturers and instrument platforms.
What applications are Thermo Fisher Scientific columns best suited for?
These columns support a wide range of applications—including pharmaceutical analysis, environmental testing, food safety workflows, and life science research—delivering reliable separations for small molecules, peptides, complex matrices, and biomolecules.