ZORBAX Eclipse XDB
Agilent ZORBAX Eclipse XDB HPLC Columns
Agilent ZORBAX Eclipse XDB columns are engineered for robust, high-performance separations across a wide pH range. Featuring Agilent’s proprietary eXtra Dense Bonding (XDB) and double endcapping, these columns deliver excellent peak shape for basic, acidic, and neutral compounds—making them a reliable, all-purpose choice for routine and advanced LC method development.
With four distinct reversed-phase selectivities (C8, C18, Phenyl-Hexyl, and CN), Eclipse XDB columns allow rapid optimization of retention and resolution. Their rugged bonded phases maintain consistent performance from pH 2 to 9, enabling durable operation under acidic and moderately basic conditions.
Available in particle sizes from 1.8 µm to 7 µm, Eclipse XDB columns support UHPLC, Rapid Resolution LC, and conventional HPLC systems—ensuring easy method transfer and scalability for pharmaceutical, environmental, food safety, and chemical analysis workflows.
Built on Agilent’s ultra-pure, high-efficiency silica, Eclipse XDB columns deliver durability, reproducibility, and chromatographic confidence across a wide variety of analytes and matrices.
XDB (eXtra Dense Bonding)
A highly stable bonding technology used in Eclipse XDB columns to improve durability, extend column lifetime, and maintain consistent performance across a wide pH range.
Double Endcapping
A secondary treatment that reduces residual silanol activity, improving peak shape—especially for basic analytes—and enhancing reproducibility.
Reversed-Phase Chromatography (RP)
A separation mode using hydrophobic stationary phases such as C18 or C8. Ideal for small molecules, pharmaceuticals, and complex organic mixtures.
Particle Size
Eclipse XDB columns offer particle sizes from 1.8–7 µm, supporting high-resolution UHPLC methods as well as robust, routine HPLC workflows with predictable method transfer.
pH Stability Range
Eclipse XDB columns perform reliably from pH 2–9, enabling robust separations of acidic, basic, and neutral compounds under varied mobile-phase conditions.
What makes Agilent ZORBAX Eclipse XDB columns unique?
Eclipse XDB columns use eXtra Dense Bonding and double endcapping to deliver strong peak shape, extended lifetime, and broad selectivity—ideal for method development on pH 2–9.
Which particle size should I choose for my method?
Use 1.8 µm for fast UHPLC separations, 3.5–5 µm for standard HPLC methods, and larger particles like 7 µm for preparative or older LC systems where lower backpressure is required.
Are Eclipse XDB columns compatible with acidic, basic, and neutral analytes?
Yes. The bonded-phase stability and double endcapping deliver excellent peak shape for analytes of all types, making Eclipse XDB phases highly versatile across multiple application spaces.
Product List
| SKU | Name | LC Column Phase | Particle Size | Inner Diameter (ID) | Length |
|---|---|---|---|---|---|
SKU
966967-905
|
Name
966967-905 - Eclipse XDB-CN, 4.6x75,3.5u
|
LC Column Phase
Eclipse XDB-CN
|
Particle Size
3.5 um
|
Inner Diameter (ID)
4.6 mm
|
Length
75 mm
|
SKU
966967-902
|
Name
966967-902 - Eclipse XDB-C18 4.6x75,3.5u Rapid Resol
|
LC Column Phase
Eclipse XDB-C18
|
Particle Size
3.5 um
|
Inner Diameter (ID)
4.6 mm
|
Length
75 mm
|
SKU
946975-906
|
Name
946975-906 - Eclipse XDB-C8,4.6x50mm,5um
|
LC Column Phase
Eclipse XDB-C8
|
Particle Size
5 um
|
Inner Diameter (ID)
4.6 mm
|
Length
50 mm
|
SKU
966954-302
|
Name
966954-302 - Eclipse XDB-C18, 3.0x75mm 3.5um
|
LC Column Phase
Eclipse XDB-C18
|
Particle Size
3.5 um
|
Inner Diameter (ID)
3 mm
|
Length
75 mm
|
SKU
946975-902
|
Name
946975-902 - Eclipse XDB-C18,4.6x50mm,5um
|
LC Column Phase
Eclipse XDB-C18
|
Particle Size
5 um
|
Inner Diameter (ID)
4.6 mm
|
Length
50 mm
|
SKU
966735-902
|
Name
966735-902 - Eclipse XDB-C18, 2.1x75mm 3.5um
|
LC Column Phase
Eclipse XDB-C18
|
Particle Size
3.5 um
|
Inner Diameter (ID)
2.1 mm
|
Length
75 mm
|
SKU
965600-906
|
Name
965600-906 - Eclipse XDB-C8, 1 x 50 mm, 3.5 micron
|
LC Column Phase
Eclipse XDB-C8
|
Particle Size
3.5 um
|
Inner Diameter (ID)
1 mm
|
Length
50 mm
|
SKU
965600-902
|
Name
965600-902 - Eclipse XDB-C18, 1 x 50 mm, 3.5 micron
|
LC Column Phase
Eclipse XDB-C18
|
Particle Size
3.5 um
|
Inner Diameter (ID)
1 mm
|
Length
50 mm
|
SKU
935967-912
|
Name
935967-912 - Eclipse XDB-Phenyl 3.5u, 4.6x50mm
|
LC Column Phase
Eclipse XDB-Phenyl
|
Particle Size
3.5 um
|
Inner Diameter (ID)
4.6 mm
|
Length
50 mm
|
SKU
963967-912
|
Name
963967-912 - Eclipse XDB-Phenyl 3.5u, 4.6 x 150mm
|
LC Column Phase
Eclipse XDB-Phenyl
|
Particle Size
3.5 um
|
Inner Diameter (ID)
4.6 mm
|
Length
150 mm
|
SKU
935967-906
|
Name
935967-906 - XDB-C8 Rapid Res 3.5um, 4.6x50mm HPLC
|
LC Column Phase
Eclipse XDB-C8
|
Particle Size
3.5 um
|
Inner Diameter (ID)
4.6 mm
|
Length
50 mm
|
SKU
963967-906
|
Name
963967-906 - Eclipse XDB-C8 3.5u 4.6 x 150 Rapid Res
|
LC Column Phase
Eclipse XDB-C8
|
Particle Size
3.5 um
|
Inner Diameter (ID)
4.6 mm
|
Length
150 mm
|