HPLC Fittings

HPLC Fittings for Secure Connections, Flow Path Reliability, and System Performance

Shop flangeless fittings, fingertight fittings, stainless steel fittings, UHPLC fittings, adapters, sleeves, plugs, caps, and tools for dependable chromatography workflows

HPLC Fittings

Chrom Tech offers a complete selection of HPLC and UHPLC fittings designed to create reliable, leak-free connections throughout your LC flow path. Choose from fingertight, flangeless, stainless-steel, and high-pressure UHPLC options to match your tubing size, solvent system, and instrument requirements—helping reduce dead volume, maintain stable backpressure, and protect chromatographic performance.

Our portfolio includes precision fittings and connection systems from trusted manufacturers such as Agilent, IDEX, Optimize Technologies, and ASI. Whether you need fast, reusable fingertight fittings for routine method changes, robust stainless-steel connectors for demanding pressures, or UHPLC solutions engineered for consistent sealing at elevated backpressure, Chrom Tech makes it easy to build the right connection every time.

Complete your setup with complementary unions, adapters, ferrules, filters, and frits across common materials including PEEK and stainless steel. For selection help and best practices, see our HPLC Fittings Guide or contact our team for application-specific recommendations.

HPLC Fitting Categories

Explore genuine Fittings from Agilent, Idex, Optimize, ASI, and more.

Key Definitions ▸
Flangeless Fitting
A tubing connection style that seals without requiring a flanged tube end, helping simplify assembly and support leak-resistant fluid connections in HPLC systems.
Fingertight Fitting
A hand-tightened fitting designed for quick installation and routine flow path connections, often used where convenient assembly and repeatable sealing are important.
UHPLC Fitting
A high-performance fitting engineered for elevated pressures and low-dead-volume connections commonly required in UHPLC applications.
Tubing Sleeve
A support component used with fittings to help position tubing correctly, improve sealing consistency, and protect tubing ends during installation.
Large Bore Fitting
A fitting designed for use with larger internal diameter tubing where higher flow capacity or reduced restriction is needed within a chromatography fluid path.
Frequently Asked Questions ▸
What types of HPLC fittings are used in chromatography systems?
HPLC systems commonly use flangeless fittings, fingertight fittings, stainless steel fittings, UHPLC fittings, adapters, sleeves, plugs, and caps to create secure flow path connections and support reliable liquid transfer.
When should I use UHPLC fittings instead of standard HPLC fittings?
UHPLC fittings are typically used when higher operating pressures and lower dead volume are required. They are designed to support high-efficiency separations where connection quality can directly affect chromatographic performance.
Why are tubing sleeves important in HPLC connections?
Tubing sleeves help position tubing correctly within the fitting assembly, which can improve sealing consistency, reduce installation errors, and help protect tubing ends from damage during connection.
What is the difference between flangeless and fingertight fittings?
Flangeless fittings seal without requiring a flanged tube end, while fingertight fittings are designed for hand tightening and convenient installation. Both can be useful depending on the pressure requirements, tubing type, and connection point in the system.
How do I choose the right HPLC fitting?
The right fitting depends on tubing dimensions, pressure requirements, instrument connection type, material compatibility, and whether the application calls for standard HPLC or UHPLC performance. Matching the fitting to the full flow path helps support leak-free and consistent operation.