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Gas bubbles and outgassing can significantly affect HPLC performance. Outgassing occurs when the dissolved gas concentration exceeds the solvent’s absorption capacity. Variables such as tempera …

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Proper mobile phase filtration is one of the most critical yet overlooked steps in HPLC. Filtering your mobile phase helps extend instrument lifespan, improve reproducibility, and prevent costly dow …

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Acetonitrile vs. Methanol in Reversed-Phase Chromatography Acetonitrile (ACN) and Methanol (MeOH) are the two most common organic modifiers used in reversed-phase HPLC. Each solvent exhibits unique …

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