UHPLC Fittings

Chrom Tech offers a focused selection of UHPLC fittings and quick-connect connection systems engineered to deliver leak-free performance at ultra-high pressures while minimizing dispersion in critical flow paths. Whether you’re upgrading an existing LC system or building a new low-dead-volume setup, these fittings help protect method integrity by maintaining consistent sealing and stable, repeatable connections.

This category includes modern connection platforms such as Agilent InfinityLab Quick Connect / Quick Turn, IDEX VHP fittings, MarvelXACT UHPLC connection systems, and Optimize EXP2 fittings. Each option is designed to reduce installation variability and improve reliability—supporting sharper peaks, lower downtime, and more confident day-to-day operation in UHPLC workflows.

Choose the best solution based on your pressure requirements, tubing and port style, and desired balance of convenience versus ultra-low dispersion. Chrom Tech stocks a wide range of configurations to support common UHPLC instruments and high-performance separations.

Key Definitions â–¶
UHPLC
Ultra-High-Performance Liquid Chromatography, a chromatography technique operating at pressures above conventional HPLC to achieve faster separations and higher resolution.
Low Dead Volume Fitting
A precision connector designed to minimize internal void space at tubing junctions, reducing band broadening and preserving chromatographic efficiency.
Quick-Connect Fitting
A tool-free fitting system that enables fast, repeatable UHPLC connections while maintaining consistent sealing pressure and alignment.
VHP (Very High Pressure)
A fitting classification indicating compatibility with extreme UHPLC operating pressures, typically exceeding 10,000 PSI.
Frequently Asked Questions â–¶
Do UHPLC fittings really improve chromatographic performance?
Yes. UHPLC fittings are engineered to minimize dead volume and maintain precise tubing alignment, which helps reduce peak broadening, improve resolution, and preserve method reproducibility at high pressures.
What’s the advantage of quick-connect UHPLC fittings?
Quick-connect systems provide consistent, tool-free connections that reduce installation variability, speed up tubing changes, and help prevent leaks caused by over- or under-tightening.
Are VHP fittings required for all UHPLC applications?
Not always. VHP fittings are recommended for systems operating at extreme pressures or when maximum reliability is required. Standard UHPLC fittings may be sufficient for lower-pressure methods within UHPLC ranges.
Can these fittings be used with different UHPLC instrument brands?
Yes. Many UHPLC fitting systems are designed for broad compatibility across major LC platforms, but thread type, tubing OD/ID, and pressure ratings should always be verified before installation.