HLB SPE Sorbent
Agilent Bond Elut HLB SPE
The Agilent Bond Elut HLB (Hydrophilic-Lipophilic Balanced) solid phase extraction (SPE) sorbent is a versatile and high-capacity solution designed for comprehensive sample preparation. Formulated with a monodisperse divinylbenzene and N-vinylpyrrolidone copolymer, Bond Elut HLB delivers balanced retention across a wide range of compound polarities.
This advanced sorbent provides superior recovery for polar, non-polar, and moderately polar compounds —including acidic, neutral, and basic analytes—making it ideal for multi-class extractions in environmental, pharmaceutical, food safety, and clinical laboratories.
Bond Elut HLB utilizes a hydrophobic/hydrophilic functional group configuration comparable to leading competitor sorbents, enabling seamless method transfer without revalidation.
Key Features
- Universal SPE sorbent suitable for diverse analyte chemistries
- High recovery rates with excellent reproducibility
- 3–10× higher adsorption capacity than C18-bonded silica gel
- Chemically stable from pH 1–14 and compatible with common organic solvents
Bond Elut HLB delivers broad retention performance across compound classes.
Frequently Asked Questions
What makes Agilent Bond Elut HLB different from traditional C18 sorbents?
Bond Elut HLB combines hydrophilic and lipophilic retention mechanisms, offering higher load capacity and broader analyte compatibility than C18-based silica sorbents.
Can Bond Elut HLB be used with both acidic and basic compounds?
Yes. The HLB copolymer chemistry ensures strong retention and recovery across acidic, neutral, and basic analytes within a wide pH range (1–14).
Is Bond Elut HLB compatible with existing SPE methods?
Yes. Its functional group balance mirrors other leading HLB sorbents, allowing for easy and direct method transfer without significant optimization.
