Sample Preparation

Chrom Tech offers a comprehensive portfolio of sample preparation products designed to improve analytical accuracy while protecting chromatography columns and instrumentation. Our selection includes solid phase extraction (SPE), supported liquid extraction (SLE), QuEChERS kits, and a full range of laboratory filtration solutions for routine and advanced workflows.

Proper sample prep plays a critical role in extending column lifetime and ensuring reproducible results. Chrom Tech supplies cost-effective filtration tools—including syringe filters, filter vials, and centrifuge filter tubes—along with higher-throughput solutions such as sample processors and evaporators to streamline laboratory operations.

We proudly feature trusted extraction technologies such as Agilent Bond Elut SPE and Agilent QuEChERS, widely used for reliable cleanup of complex matrices in food, environmental, pharmaceutical, and bioanalytical applications.

Whether you’re performing routine sample cleanup or building a complete preparation workflow, Chrom Tech delivers dependable solutions backed by chromatography expertise. For assistance selecting SPE, SLE, or filtration products, contact our Chrom Tech team for personalized support.

Key Definitions ▶
Sample Preparation
The process of cleaning, extracting, and conditioning samples prior to chromatographic analysis to improve accuracy and protect analytical systems.
Solid Phase Extraction (SPE)
A cleanup technique that uses sorbent media to selectively retain analytes while removing interfering matrix components.
Supported Liquid Extraction (SLE)
An extraction method that replaces traditional liquid-liquid extraction by absorbing aqueous samples onto a solid support before elution with organic solvent.
QuEChERS
A rapid sample preparation approach (Quick, Easy, Cheap, Effective, Rugged, and Safe) commonly used for extracting pesticides and residues from food and environmental samples.
Laboratory Filtration
The removal of particulates from samples using syringe filters, filter vials, or membranes to prevent column clogging and improve chromatographic reproducibility.
Frequently Asked Questions ▶
Why is sample preparation important for chromatography?
Sample preparation removes particulates and matrix contaminants that can foul injector components, clog frits, and shorten column life—helping deliver cleaner baselines, more consistent retention, and reproducible quantitative results.
What are the benefits of Agilent Bond Elut SPE cartridges?
Bond Elut SPE cartridges are designed for reliable retention and cleanup with consistent bed packing and flow performance. They help reduce matrix effects, improve recoveries, and support repeatable sample preparation across routine and regulated workflows.
What is the difference between SPE and SLE?
SPE uses a sorbent to selectively retain analytes (or interferences) followed by controlled washing and elution. SLE supports aqueous samples on an inert medium and relies on partitioning into an organic solvent—often providing simpler workflows for liquid-liquid style extractions with fewer emulsions.
How do I choose the right syringe filter for my samples?
Match the membrane to your solvent chemistry and analytes, and select a pore size that protects your column without restricting flow (commonly 0.2–0.45 µm). If you’re unsure, start with chemical compatibility first, then optimize pore size and diameter for throughput and sample cleanliness.