Regis

Regis HPLC columns are engineered for high-performance chiral and achiral separations, delivering exceptional selectivity, reproducibility, and long-term stability across pharmaceutical, biochemical, and environmental workflows. Featuring proprietary stationary phases and robust manufacturing standards, Regis columns support both routine analyses and advanced method development.

The Pirkle Chiral series—including Whelk-O® 1 and RegisPack™—provides powerful enantiomeric separations through Pirkle-type π–π, dipole, and hydrogen-bonding interactions for precise chiral discrimination. For membrane-interaction studies, the IAM (Immobilized Artificial Membrane) column family replicates phospholipid bilayers, enabling accurate assessment of drug–membrane affinity, lipophilicity, and permeability.

Chrom Tech supplies the complete lineup of Regis HPLC technologies and provides expert assistance in selecting the optimal column for enantiomeric resolution, drug-interaction profiling, impurity analysis, or complex small-molecule separations. For personalized support, contact Chrom Tech.

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Key Definitions ▸
Chiral Chromatography
A separation technique used to resolve enantiomers (mirror-image molecules) common in pharmaceuticals and fine chemicals. Selectivity is driven by stereospecific interactions between analytes and a chiral stationary phase.
Pirkle-Type Chiral Recognition
A chiral separation mechanism that leverages π–π, hydrogen bonding, and dipole interactions to distinguish enantiomers—core to the selectivity of Whelk-O® 1 and RegisPack™ columns.
IAM (Immobilized Artificial Membrane)
A biomimetic stationary phase that imitates phospholipid membranes, enabling measurement of drug–membrane interactions, lipophilicity, and passive permeability with high biological relevance.
Enantiomeric Separation
The process of separating left- and right-handed molecular forms—critical for pharmaceutical purity, impurity profiling, and evaluating differences in biological activity between enantiomers.
Achiral Chromatography
Separation of non-chiral compounds using standard reversed-phase, normal-phase, or ion-exchange chemistries—commonly paired with chiral methods during pharmaceutical method development.
Frequently Asked Questions ▸
What are Pirkle Chiral columns used for?
Pirkle Chiral columns, such as Whelk-O® 1 and RegisPack™, are designed for high-selectivity enantiomeric separations using π–π, dipole, and hydrogen-bonding interactions. They are widely used in pharmaceutical purity testing, chiral method development, and fine chemical analysis.
How do IAM columns differ from standard reversed-phase columns?
IAM (Immobilized Artificial Membrane) columns mimic biological phospholipid membranes, allowing direct measurement of lipophilicity, passive permeability, and drug–membrane interactions—properties difficult to characterize using conventional reversed-phase stationary phases.
Are Regis HPLC columns compatible with standard HPLC and UHPLC systems?
Yes. Regis columns are fully compatible with conventional HPLC and UHPLC systems and are available in multiple dimensions, particle sizes, and chiral/achiral chemistries to integrate seamlessly into existing methods.