Whelk-O® 1 | Analytical to Preparative Columns
The Whelk-O® 1 is useful for the separation of underivatized enantiomers in a number of families including amides, epoxides, esters, ureas, carbamates, ethers, aziridines, phosphonates, aldehydes, ketones, carboxylic acids, alcohols, and non-steroidal anti-inflammatory drugs (NSAIDs). This π-electron acceptor/ π-electron donor phase exhibits an extraordinary degree of generality. The broad versatility observed on the Whelk-O® 1 column compares favorably with polysaccharide-derived chiral stationary phases.
In addition, because Whelk-O® 1 is covalently bonded to the support, the phase is compatible with all commonly used mobile phases, including aqueous systems — a distinct advantage over polysaccharide derived chiral stationary phases. Other advantages include column durability, excellent efficiency, ability to invert elution order, and excellent preparative capacity.
RegisPack™ polysaccharide coated chiral columns are made using a unique production process of coating the proven chiral selector tris-(3,5-dimethylphenyl) carbamoyl amylose on high purity silica gel. RegisPack™ columns are available in 3, 5, 10, and 20 micron particle sizes enabling easy scale up from analytical to preparative using HPLC or SFC conditions. Bulk material is available upon request.