Pursuit XRs

Agilent Pursuit XRs HPLC Columns

Agilent Pursuit XRs columns are engineered for high-resolution, high-loading performance across analytical and preparative HPLC workflows. Built on ultra-high-purity silica with tightly controlled pore structures, Pursuit XRs columns deliver exceptional peak shape, reproducibility, and ruggedness—making them a reliable choice for pharmaceuticals, environmental testing, food safety, and complex mixture analysis.

Designed to meet diverse chromatographic needs, Agilent offers both the standard Pursuit phases and the high-carbon-load Pursuit XRs chemistries. These phases span key USP classifications—including USP L1, L7, and L11—to provide predictable performance and easy method transfer across laboratories. With particle sizes ranging from analytical-scale options to large-diameter preparative columns, users can seamlessly scale from development to purification.

The Pursuit XRs line is specifically optimized for enhanced retention of hydrophobic analytes, superior loadability, and consistent performance under aggressive gradient conditions. These columns support high sample throughput and strong method robustness, helping labs achieve precise separations even with demanding matrices or regulatory-driven assays.

Chrom Tech offers the full portfolio of Pursuit and Pursuit XRs HPLC columns, along with expert technical guidance to help you select the ideal phase, dimensions, and particle size for your workflow. For assistance or additional recommendations, contact our technical support team here.

Agilent Pursuit XRs — Phase Descriptions ▸
Pursuit XRs C8
C8 • 100 Å • Fully Porous • High-efficiency small particle options
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Pursuit XRs C8 delivers reduced hydrophobic retention compared to C18, making it ideal for faster gradients and improved throughput. Built on high-purity silica, it provides consistent peak shape for acids, bases, and neutral compounds in routine HPLC and UHPLC workflows.

Best For
  • Retention tuning when C18 retention is too strong
  • Fast pharmaceutical and impurity profiling methods
  • High-throughput reversed-phase workflows
Key Specifications
Separation ModeReversed phase
Bonded PhaseC8 (octylsilane)
Pore Size100 Ã…
Particle TypeFully porous silica
Typical Particle Sizes2–5 µm (format dependent)
pH Range2–8 (typical silica operating range)
Pursuit XRs C18
C18 • 100 Å • Fully Porous • High-efficiency reversed phase
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Pursuit XRs C18 is a versatile reversed-phase column offering strong hydrophobic retention and broad analyte compatibility. It is commonly selected for pharmaceutical development, impurity analysis, and general small-molecule separations requiring robust and reproducible performance.

Best For
  • General-purpose method development
  • Pharmaceutical QC and stability testing
  • High-resolution small-molecule separations
Key Specifications
Separation ModeReversed phase
Bonded PhaseC18 (octadecylsilane)
Pore Size100 Ã…
Particle TypeFully porous silica
Typical Particle Sizes2–5 µm (format dependent)
pH Range2–8 (typical silica operating range)
Pursuit XRs Diphenyl
Diphenyl • 100 Å • Aromatic selectivity • Fully porous
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Pursuit XRs Diphenyl enhances aromatic selectivity through π–π interactions, making it ideal for separating conjugated, aromatic, and isomeric compounds. It offers meaningful selectivity shifts compared to C18, often resolving critical pairs without major method revalidation.

Best For
  • Aromatic and polyaromatic compounds
  • Isomer separations requiring alternate selectivity
  • LC-MS methods needing changed retention order
Key Specifications
Separation ModeReversed phase
Bonded PhaseDiphenyl
Pore Size100 Ã…
Particle TypeFully porous silica
Typical Particle Sizes2–5 µm (format dependent)
pH Range2–8 (typical silica operating range)

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SKU Name LC Column Phase Particle Size Inner Diameter (ID) Length
SKU
A6001050X020
Name
A6001050X020 - Pursuit XRs 3 C18 50 x 2.0mm
LC Column Phase
C18
Particle Size
3 um
Inner Diameter (ID)
2 mm
Length
50 mm
SKU
A6011050X020
Name
A6011050X020 - Pursuit XRs 3 C8 50 x 2.0mm
LC Column Phase
C8
Particle Size
3 um
Inner Diameter (ID)
2 mm
Length
50 mm
SKU
A6021250X020
Name
A6021250X020 - Pursuit XRs 3 Diphenyl 250 x 2.0mm
LC Column Phase
Diphenyl
Particle Size
3 um
Inner Diameter (ID)
2 mm
Length
250 mm
SKU
A6021150X046
Name
A6021150X046 - Pursuit XRs 3 Diphenyl 150 x 4.6mm
LC Column Phase
Diphenyl
Particle Size
3 um
Inner Diameter (ID)
4.6 mm
Length
150 mm
SKU
A6001020X020
Name
A6001020X020 - Pursuit XRs 3 C18 20 x 2.0mm
LC Column Phase
C18
Particle Size
3 um
Inner Diameter (ID)
2 mm
Length
20 mm
SKU
A6021150X030
Name
A6021150X030 - Pursuit XRs 3 Diphenyl 150 x 3.0mm
LC Column Phase
Diphenyl
Particle Size
3 um
Inner Diameter (ID)
3 mm
Length
150 mm
SKU
A6021150X020
Name
A6021150X020 - Pursuit XRs 3 Diphenyl 150 x 2.0mm
LC Column Phase
Diphenyl
Particle Size
3 um
Inner Diameter (ID)
2 mm
Length
150 mm
SKU
A6010150X046
Name
A6010150X046 - Pursuit XRs 5 C8 150 x 4.6mm
LC Column Phase
Particle Size
5 um
Inner Diameter (ID)
Length
150 mm
SKU
A6021100X046
Name
A6021100X046 - Pursuit XRs 3 Diphenyl 100 x 4.6mm
LC Column Phase
Diphenyl
Particle Size
3 um
Inner Diameter (ID)
4.6 mm
Length
100 mm
SKU
A6021100X030
Name
A6021100X030 - Pursuit XRs 3 Diphenyl 100 x 3.0mm
LC Column Phase
Diphenyl
Particle Size
3 um
Inner Diameter (ID)
3 mm
Length
100 mm
SKU
A6010150X030
Name
A6010150X030 - Pursuit XRs 5 C8 150 x 3.0mm
LC Column Phase
Particle Size
5 um
Inner Diameter (ID)
Length
150 mm
SKU
A6021100X020
Name
A6021100X020 - Pursuit XRs 3 Diphenyl 100 x 2.0mm
LC Column Phase
Diphenyl
Particle Size
3 um
Inner Diameter (ID)
2 mm
Length
100 mm
Key Definitions â–¸
High Carbon Load Bonding
A bonding strategy that increases the hydrophobic carbon density on the silica surface, delivering stronger retention, enhanced selectivity, and improved phase durability. Pursuit XRs phases are engineered with elevated carbon load for consistent reversed-phase performance.
Fully Porous Silica (FPP)
Silica particles that are porous throughout their entire structure, providing high loading capacity, strong analyte interaction, and robust mechanical stability in analytical and preparative HPLC columns.
USP L-Classifications
United States Pharmacopeia (USP) designations that define stationary phase selectivity. Pursuit XRs phases include L1 (C18), L7 (C8), and L11 (Diphenyl), supporting regulated method development and validation workflows.
Diphenyl Selectivity
A stationary phase containing two phenyl rings that enhance π–π interactions and shape selectivity, improving resolution of aromatic, conjugated, and structurally similar compounds.
Retention Stability
The ability of a column to maintain consistent retention times and selectivity across injections and batches, critical for QC reproducibility and method transfer.
Frequently Asked Questions â–¸
What is the difference between Pursuit and Pursuit XRs columns?
Standard Pursuit columns use traditional bonding chemistry, while Pursuit XRs columns feature a high-carbon-load surface that increases hydrophobic retention, improves resolution, and enhances separation of difficult or strongly retained analytes.
Which USP phases are available in the Pursuit XRs family?
Pursuit XRs columns are available in common USP classifications including L1 (C18), L7 (C8), and L11 (Diphenyl), supporting pharmaceutical and regulated LC method development.
Are Pursuit XRs columns suitable for preparative HPLC?
Yes. Pursuit XRs columns are available in analytical and preparative dimensions, providing strong loadability, mechanical durability, and consistent selectivity for purification workflows.
What applications benefit most from Pursuit XRs columns?
Pursuit XRs columns are ideal for pharmaceutical, environmental, and food analysis where enhanced hydrophobic retention, improved resolution, and long-term retention stability are required.