Optimize EXP2 Fittings

Optimize EXP2 UHPLC fittings are engineered for ultra-high-pressure liquid chromatography applications requiring reliable, repeatable, and tool-free connections. Designed to withstand extreme operating conditions, EXP2 fittings deliver secure, zero-dead-volume sealing for both standard and nano UHPLC workflows—making them ideal for UHPLC and UHPLC/MS systems where performance consistency is critical.

  • Hand-tight rated to 20,000+ PSI (1,400+ bar) for true tool-free operation
  • Auto-adjusting, zero-dead-volume design helps preserve peak shape and chromatographic resolution
  • One-piece ferrule construction provides exceptional durability and long service life
  • Compatible with standard and nano UHPLC as well as UHPLC/MS applications
  • Manufactured in the USA for consistent quality and performance

The robust EXP2 ferrule automatically compensates for minor variations in capillary length, ensuring reliable sealing across repeated installations without retightening. This simplifies system setup, reduces leak risk, and minimizes downtime during method development or routine maintenance.

Due to the tight tolerances of the EXP ferrule, Chrom Tech recommends using VICI pre-cut stainless steel tubing when stainless steel capillaries are preferred, helping ensure optimal fit and consistent performance.

Chrom Tech offers a full range of Optimize EXP2 fittings and accessories, with many popular configurations in stock and ready to ship—making it easy to upgrade your UHPLC connections with confidence.

Part No Tubing OD Nut Ferrule Driver
Optimize EXP2 Fitting with EXP Ferrule
15-20-04933 1/16", SS or PEEK (2) 10-32 EXP2 Nut (2) EXP Ferrule (1) EXP2 Driver
15-20-04924 1/16", SS or PEEK (10) 10-32 EXP2 Nut (10) EXP Ferrule (1) EXP2 Driver
15-24-03832 Replacement EXP Ferrules for 1/16" OD Tubing, 10/pk
Optimize EXP2 Fitting with Ti-LOK Ferrule
15-20-04932 1/16", PEEKsil (2) 10-32 EXP2 Nut (2) Ti-LOK Ferrule (1) EXP2 Driver
15-20-04920 1/16", PEEKsil (10) 10-32 EXP2 Nut (10) Ti-LOK Ferrule (1) EXP2 Driver
15-19-04930 1/32", PEEKsil (2) 6-32 EXP2 Nut (2) Ti-LOK Ferrule (1) EXP2 Driver
15-19-04929 1/32", PEEKsil (10) 6-32 EXP2 Nut (10) Ti-LOK Ferrule (1) EXP2 Driver
15-19-04931 1/32", PEEKsil (2) 6-40 EXP2 Nut (2) Ti-LOK Ferrule (1) EXP2 Driver
15-19-04927 1/32", PEEKsil (10) 6-40 EXP2 Nut (10) Ti-LOK Ferrule (1) EXP2 Driver
Part No Description
Optimize EXP Fittings for 1/16" OD Tubing (SS or PEEK)
15-20-03930 10-32 Hand-Tight EXP Nut & EXP Ferrule
15-24-03832 Replacement EXP Ferrules
Part No ID Length
VICI Precut Stainless Steel (2/pk), 1/16" OD
T30C5D0.005" (0.125 mm)12" (30 cm)
T50C5D0.005" (0.125 mm)1.6' (50 cm)
T20C10D0.010" (0.25 mm)8" (20 cm)
T30C10D0.010" (0.25 mm)12" (30 cm)
T50C10D0.010" (0.25 mm)1.6' (50 cm)
T20C20D0.020" (0.5 mm)8" (20 cm)
T30C20D0.020" (0.5 mm)12" (30 cm)
T50C20D0.020" (0.5 mm)1.6' (50 cm)
T20C30D0.030" (0.75 mm)8" (20 cm)
T30C30D0.030" (0.75 mm)12" (30 cm)
T50C30D0.030" (0.75 mm)1.6' (50 cm)
Key Definitions â–¸
Optimize EXP2 Fittings
High-pressure UHPLC fittings designed for tool-free operation up to 20,000+ PSI, providing reliable, repeatable, zero-dead-volume connections for analytical and mass spectrometry workflows.
Hand-Tight UHPLC Connection
A fitting interface that achieves full pressure sealing without tools, reducing setup time while maintaining leak-free performance under ultra-high-pressure conditions.
Auto-Adjusting Ferrule
An integrated ferrule design that compensates for small variations in capillary length, ensuring consistent sealing and zero-dead-volume alignment across repeated installations.
Zero Dead Volume
A connection geometry that eliminates internal voids between tubing and ports, helping preserve peak shape, reduce carryover, and improve chromatographic accuracy.
UHPLC / UHPLC-MS
Ultra-High Performance Liquid Chromatography and UHPLC coupled with mass spectrometry—analytical techniques that operate at elevated pressures to achieve faster separations, higher resolution, and enhanced sensitivity.
Frequently Asked Questions â–¸
What makes Optimize EXP2 fittings different from standard UHPLC fittings?
Optimize EXP2 fittings are hand-tight rated to 20,000+ PSI and feature an auto-adjusting, one-piece ferrule that delivers consistent zero-dead-volume sealing across repeated connections—eliminating the need for tools while maintaining ultra-high-pressure reliability.
Are tools required to install EXP2 fittings?
No. EXP2 fittings are designed for true hand-tight installation, even at ultra-high pressures, helping reduce setup time while minimizing the risk of over-tightening or port damage.
Can EXP2 fittings be reused with different capillaries?
Yes. The robust one-piece ferrule design allows EXP2 fittings to be reused with multiple capillaries without compromising sealing performance, making them ideal for method development and routine system changes.
Which applications benefit most from Optimize EXP2 fittings?
EXP2 fittings are well suited for UHPLC, nano-UHPLC, and UHPLC/MS workflows in pharmaceutical, proteomics, metabolomics, and analytical research laboratories where zero dead volume and pressure stability are critical.
Why is VICI stainless steel tubing recommended with EXP2 fittings?
Due to the tight tolerances of the EXP2 ferrule, VICI pre-cut stainless steel tubing provides consistent dimensional accuracy, helping ensure proper seating, reliable sealing, and optimal long-term performance.

Optimize EXP2 Fittings for Hand-Tight UHPLC Connections

  • Rated Hand-Tight to 20,000+ PSI (1,400+ bar)
  • Auto-adjusting, zero-dead-volume connection
  • Extremely robust one-piece ferrule design
  • Perfect for standard or nano UHPLC and UHPLC/MS
  • Made in U.S.A.

Due to the tight tolerances of the EXP ferrule, we recommend using VICI tubing if Stainless Steel tubing is preferred.