New and Dangerous Synthetic Opioids

Are New Synthetic Opioids Increasing Risks?

Synthetic opioids are critical tools in modern medicine for managing severe pain. However, their extreme potency and addictive potential make them dangerous when misused. Drugs such as fentanyl and its analogs have become increasingly prevalent in illicit markets, often leading to accidental overdoses. Even microgram-level exposure can be fatal, underscoring the urgent need for improved detection and awareness in both clinical and forensic settings.

What Are Some of the Newest Synthetic Opioids?

Among synthetic opioids, fentanyl and its derivatives remain the most commonly trafficked. A recent variation known as “Rainbow Fentanyl” has drawn national attention for its bright, candy-like appearance, raising public safety concerns that it could be mistaken for sweets or used to target children. Fentanyl is more than 50 times stronger than heroin and 100 times stronger than morphine, making accidental overdoses increasingly likely.

Another emerging compound, N-pyrrolidino Etonitazene—commonly referred to as “Pyro”—has been identified in Colorado and linked to fatal overdoses. “Pyro” is estimated to be over 10 times more potent than fentanyl and can appear nearly identical to fentanyl tablets, making it particularly dangerous for users and law enforcement to identify.

How to Test for New Synthetic Opioids

As novel opioids continue to appear, laboratories need reliable analytical tools that can detect a wide range of compounds efficiently. The Raptor™ Biphenyl LC Column has been successfully utilized in LC-MS/MS methods for detecting over 230 drugs and metabolites across diverse compound classes. Its versatile retention profile makes it ideal for comprehensive drug screening applications. For a full methodology, refer to Chrom Tech’s application note, “Revisiting The Big Pain.”

For the latest forensic and toxicology applications, explore Chrom Tech’s mini catalog or contact our product specialists for expert guidance on choosing the right analytical columns and supplies for your testing needs.

References

1. Public Health Alert: Deadly “Rainbow Fentanyl” (Chautauqua County Health Department)

2. DEA: New Dangerous Synthetic Opioid Emerging in the Tri-State Area