Filters

Solvent Inlet Filters, Inline Filters, Precolumn Filters, and Frits

Chrom Tech supplies a full range of HPLC solvent inlet filters, inline filters, precolumn filters, and replacement frits engineered to maintain clean mobile-phase flow, protect system components, and extend analytical column life. From standard and bottom-of-bottle inlet filters to Agilent InfinityLab quick-change inline designs, each option delivers reliable particulate retention with simple, service-friendly maintenance.

Precolumn filters and microfilters capture debris before it reaches the stationary phase, helping safeguard column frits while reducing downtime and replacement costs. Available in stainless steel and PEEK constructions, these filters provide excellent chemical resistance and support consistent chromatographic performance across routine and sensitive workflows.

Chrom Tech also offers inline solvent filters and biocompatible microfilters for low-volume venting applications, along with Frit-in-a-Ferrule components that combine sealing and filtration in a single compact fitting—ideal for space-constrained LC flow paths.

Application Highlights

• Protects pumps, injectors, and columns from particulate contamination
• Extends column life by trapping debris upstream
• Stainless steel and PEEK options for standard or bio-compatible workflows
• Inline, inlet, precolumn, and frit solutions for complete LC filtration coverage

Chrom Tech stocks a broad selection of filtration components to support HPLC and UHPLC systems, with many common configurations available for fast shipment.

HPLC Filter Categories

Protect pumps, columns, and detectors by selecting the right LC filtration point—from bottle inlet protection to inline and precolumn filtration, plus replacement frits for maintenance.

Key Definitions â–¶
Solvent Inlet Filter
A filter installed at the solvent bottle or reservoir to trap particulates before they enter the pump and high-pressure LC flow path.
Inline Filter
A flow-path filter installed between LC components to capture debris and protect injectors, columns, and detectors from particulate contamination.
Precolumn Filter
A filter placed directly upstream of the analytical column to prevent particulates from reaching the column inlet frit and stationary phase.
Microfilter
A compact, fine-porosity filter used in low-volume or micro-flow LC paths to retain particulates while minimizing dead volume.
Frit
A porous element that retains particles while allowing solvent flow; commonly used inside filter housings, unions, and column interfaces.
Frit-in-a-Ferrule
A compact component that integrates filtration and sealing in one fitting, helping reduce parts count and maintain low-dead-volume connections.
Frequently Asked Questions â–¶
What is the purpose of solvent inlet and inline filters?
Solvent inlet and inline filters capture particulates before they enter sensitive LC components, helping protect pumps, injectors, and columns while supporting stable pressure and consistent chromatography.
How do precolumn filters help extend column life?
Precolumn filters trap debris upstream of the analytical column, preventing particles from reaching the column frit and stationary phase—reducing plugging and extending usable column life.
What materials are available for these filters?
Chrom Tech offers filters in stainless steel and PEEK to support standard HPLC workflows as well as bio-compatible and corrosion-resistant applications.
What is a frit-in-a-ferrule?
A frit-in-a-ferrule combines filtration and sealing in one compact fitting, reducing parts count while maintaining low-dead-volume connections in space-constrained LC flow paths.
How often should LC filters be replaced?
Replacement frequency depends on sample cleanliness and system usage. Rising backpressure, unstable flow, or reduced performance typically indicate it’s time to replace or clean filters and frits.