HP-INNOWax

Agilent HP-INNOWax GC Columns

Agilent HP-INNOWax GC columns are high-polarity polyethylene glycol (PEG) columns designed for exceptional separation of alcohols, organic acids, esters, aldehydes, ketones, and other oxygenated compounds. As Agilent’s premium bonded PEG solution, HP-INNOWax offers greater thermal stability and longer column lifetime than traditional unbonded WAX phases, making it an outstanding choice for food, flavor/fragrance, environmental, and industrial applications requiring highly reliable analysis of polar analytes.

HP-INNOWax features higher maximum operating temperatures compared to standard PEG columns, allowing faster elution of late-boiling compounds and improved overall cycle times. Its bonded, crosslinked chemistry provides robust performance under demanding conditions, ensuring stable retention behavior, minimal stationary-phase bleed, and consistently sharp peak shapes—critical for trace-level GC/MS work.

  • Polyethylene glycol (PEG) stationary phase with strong polar selectivity
  • High polarity ideal for alcohols, glycols, acids, esters, and other oxygenated species
  • Higher upper temperature limits than standard PEG phases for faster, more robust workflows
  • Excellent column-to-column repeatability for reliable method transfer
  • Bonded and crosslinked for enhanced thermal stability and longer column lifetime
  • Solvent-rinsable to restore performance in complex or dirty matrix applications
  • Close equivalent to USP Phase G16

Similar Phases: SUPELCOWAX 10, SUPEROX II, CB-WAX, Stabilwax, BP-20, 007-CW, Carbowax, ZB-WAX, ZB-WAX+

Key Definitions â–¸
Polyethylene Glycol (PEG) Phase
A highly polar stationary phase based on polyethylene glycol polymers. PEG phases such as HP-INNOWax are widely used for separating alcohols, organic acids, esters, aldehydes, ketones, and other oxygenated compounds due to strong hydrogen-bonding interactions.
Bonded and Crosslinked
A chemical reinforcement process that binds and crosslinks the stationary phase to the capillary surface. This improves thermal stability, reduces column bleed, enables solvent-rinsing, and extends column lifetime compared to unbonded PEG WAX phases.
High Polarity
Indicates the column’s strong selectivity for polar analytes. High-polarity phases such as HP-INNOWax exhibit enhanced interaction with alcohols, glycols, acids, esters, and other oxygenated species, enabling precise separation even for closely related compounds.
USP Phase G16
A United States Pharmacopeia classification for strongly polar PEG columns. HP-INNOWax being equivalent to USP G16 ensures compatibility with regulated, compendial, and validated methods requiring this selectivity profile.
Column-to-Column Repeatability
The manufacturing consistency that ensures identical retention behavior across multiple columns. HP-INNOWax offers excellent repeatability, making it ideal for validated methods, regulated testing, and multi-system laboratory environments.
Frequently Asked Questions â–¸
What types of compounds are best analyzed using HP-INNOWax columns?
HP-INNOWax columns excel at separating polar, oxygenated compounds such as alcohols, organic acids, esters, aldehydes, ketones, glycols, flavor compounds, and food-related volatiles. Their high polarity provides outstanding selectivity for analytes that are difficult to resolve using nonpolar or mid-polar phases.
How is HP-INNOWax different from traditional WAX or Carbowax-type columns?
HP-INNOWax is bonded and crosslinked, giving it higher thermal stability and lower bleed than unbonded WAX phases. This results in longer column lifetime, cleaner baselines, solvent-rinsability, and improved performance in GC and GC/MS workflows requiring greater robustness and repeatability.
Is HP-INNOWax suitable for GC/MS applications?
Yes. The column’s bonded PEG phase yields very low bleed, making it highly compatible with GC/MS. Its stability at elevated temperatures and clean background reduces noise and supports lower detection limits, especially for polar analytes requiring sensitive mass spectral analysis.
Can HP-INNOWax be solvent rinsed?
Yes. Because HP-INNOWax is bonded and crosslinked, it is solvent-rinsable, allowing users to remove nonvolatile contaminants and restore performance when analyzing dirty or complex matrix samples. This greatly extends column lifetime compared to unbonded PEG phases.
Does HP-INNOWax meet compendial or regulatory method requirements?
Yes. HP-INNOWax is a close equivalent to USP Phase G16, making it suitable for pharmacopeial, regulated, or validated methods that specify this selectivity. Its excellent reproducibility supports reliable method transfer and compliance.