Guard Columns
Guard Columns
Poroshell 120
HPLC Columns
HPLC Guard Columns
Guard columns are protective cartridges placed between the injector and the analytical column. They trap particulate matter using a frit and capture compounds that could strongly or irreversibly bind to the analytical stationary phase. By serving as a sacrificial barrier, guard columns extend the lifespan and performance of your primary column.
Most guard columns are packed with the same stationary phase as their matching analytical column to preserve separation characteristics and ensure retention consistency. Chrom Tech carries IDEX unpacked guards, EXP high-pressure guard cartridges, and Agilent InfinityLab Poroshell 120 guards to fit a wide range of HPLC applications.
For additional LC column and phase options, visit our LC Columns page, or contact our technical team for expert guidance on selecting compatible guard assemblies.
Frequently Asked Questions
What is the purpose of a guard column in HPLC?
A guard column protects the main analytical column from contamination by trapping particulates and strongly retained compounds, helping maintain resolution and extend column life.
How often should I replace my guard column?
Replace the guard column whenever backpressure increases, peak shape deteriorates, or retention time shifts occur. Frequency depends on sample cleanliness and solvent quality.
Do guard columns affect chromatographic performance?
When packed with the same stationary phase as the analytical column, guard columns preserve chromatographic integrity while protecting against contamination.
What pressure can EXP guard cartridges withstand?
EXP guard cartridges from IDEX are rated up to 15,000 PSI and feature a hand-tight connection system for secure, leak-free installations in UHPLC applications.
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