DB-624

DB-624 column

Agilent DB-624 GC Columns

Agilent J&W DB-624 GC columns are engineered for high-performance analysis of volatile organic pollutants (VOCs) using GC and GC/MS. With proven selectivity and rugged performance, DB-624 is widely used across environmental, pharmaceutical, food, and industrial testing workflows. It is specifically recommended for residual solvent analysis per USP Monograph <467> and is validated for numerous Environmental Protection Agency (EPA) VOC methods, including 501.3, 502.2, 503.1, 524.2, 601, 602, 8010, 8015, 8020, 8021, 8240, and 8260. This broad method compatibility has made DB-624 one of the most trusted and widely adopted VOC columns in regulatory laboratories worldwide.

DB-624, equivalent to USP phase G43, features a mid-polar stationary phase composed of 6% cyanopropyl/phenyl and 94% polydimethylsiloxane—offering strong retention and reliable separation of alcohols, ketones, esters, halogenated solvents, and other regulated volatiles. The phase is bonded, crosslinked, and fully solvent-rinseable, providing extended durability and stable performance across a wide operating temperature range from –20 Â°C to 260 Â°C.

Each DB-624 column undergoes rigorous Agilent quality control testing, including the industry’s tightest specifications for bleed, sensitivity, and efficiency, ensuring consistent performance for both routine and trace-level VOC analysis. As an authorized distributor of Agilent GC columns, Chrom Tech offers DB-624 as a dependable, high-quality solution for laboratories requiring robust selectivity, regulatory compliance, and long-term reproducibility in VOC workflows.
Key Definitions â–¸
DB-624
A mid-polar GC column composed of 6% cyanopropyl/phenyl and 94% polydimethylsiloxane. DB-624 is widely used for VOC analysis and is validated for multiple EPA and USP residual solvent methods.
USP Phase G43
A United States Pharmacopeia stationary phase classification corresponding to a 6% cyanopropylphenyl, 94% polydimethylsiloxane phase. DB-624 meets this specification and is suitable for USP <467> residual solvent testing.
EPA VOC Methods
U.S. EPA analytical methods for volatile organic compounds, including 501.3, 502.2, 503.1, 524.2, 601, 602, 8010, 8015, 8020, 8021, 8240, and 8260. These methods require dependable VOC retention, low bleed, and strong inertness for accurate quantitation.
Bonded and Crosslinked Phase
A stationary phase chemically attached to the column’s silica surface and crosslinked for maximum durability. DB-624’s bonded and crosslinked design allows solvent rinsing and ensures long-term thermal stability across routine and regulatory VOC analyses.
Frequently Asked Questions â–¸
What applications are best suited for the DB-624 column?
DB-624 is ideal for analyzing volatile organic compounds (VOCs) in environmental, pharmaceutical, food, and industrial samples. It is widely used for EPA VOC methods and USP <467> residual solvent testing due to its proven selectivity and rugged performance.
How does DB-624 compare to DB-624 UI?
Both columns share the same 624 stationary phase and equivalent USP G43 classification. However, DB-624 UI features Agilent Ultra Inert deactivation for improved peak shape and sensitivity of active VOCs, making it more suitable for low-level GC/MS applications.
What temperature range can DB-624 operate in?
DB-624 is bonded, crosslinked, and solvent-rinseable with a recommended operating temperature range of –20 °C to 260 °C. This makes it suitable for a wide variety of VOC methods requiring thermal stability and reproducible retention characteristics.
Why is DB-624 popular for regulatory VOC workflows?
DB-624 offers consistent selectivity, low bleed, and strong retention characteristics that align with major EPA VOC methods and USP <467> guidelines. Its durability and stringent QC testing ensure reliable, repeatable performance for compliance-driven laboratories.