Posted by Chrom Tech on 14th Oct 2025
EHS Compliance: Safely Manage HPLC Solvent Waste
Many solvents and samples used in high-performance liquid chromatography (HPLC) are flammable or hazardous. To protect your lab and personnel, proper HPLC solvent waste disposal is critical. Chrom Tech offers compliant, easy-to-use waste containment systems designed to minimize exposure and keep your laboratory up to code.
Common Red Flags in HPLC Waste Disposal
While four-liter amber bottles are frequently used in laboratories, they often do not meet safety or EPA compliance standards for solvent waste containment. Some key issues include:
- Using aluminum foil or parafilm around the bottle’s neck does not create a proper closed seal.
- Amber bottles have a narrow base and are prone to tipping, posing a spill and exposure risk.
Comply with EPA Standards and Protect Your Team
If your lab’s current waste setup doesn’t meet safety standards, Chrom Tech’s HPLC solvent waste containment kit offers an affordable and effective solution—typically for less than the cost of an HPLC column. Each kit includes a 6-port manifold and necessary fittings for nearly any HPLC configuration, ensuring a closed, compliant system.
Closed-System Design for Maximum Safety
Each safety kit includes two quick-connect fittings—one for the 6-port manifold and one for the activated carbon vapor filter. These components create a fully closed system that prevents solvent vapors from escaping, keeping lab air clean and safe. The carbon filters capture harmful chemical vapors and typically need replacement every three to six months, depending on usage.
Overflow Protection and Secondary Containment
Proper planning prevents spills. The 6-port manifold’s small internal volume allows collection to continue even when disconnected from the waste can, so your HPLC can keep running during maintenance. To prevent overflow, always pair your system with a secondary containment basin. In the event of an overfill, excess solvent is safely routed through the vapor filter into the backup container—preventing backflow into the HPLC system.
Choosing the Right Safety Kit
The SAFETY-5PP-E is Chrom Tech’s most popular model, featuring a five-gallon translucent polyethylene can with polypropylene fittings. The EPDM O-ring used in PP kits offers broad solvent compatibility for reversed-phase HPLC solvents.
For normal-phase or GPC solvents, Chrom Tech also offers stainless steel quick-connect kits with PTFE O-rings. Both PP and SS versions are available in two- or five-gallon can sizes for flexibility across lab setups.
Storage Solutions for Flammable and Hazardous Materials
As an authorized distributor of Justrite safety products, Chrom Tech also offers solvent storage cabinets and chemical safety accessories. Our product specialists can provide tailored quotes to help your lab meet fire code and EPA compliance requirements.
Conclusion
Don’t wait for a safety citation to address solvent waste management. Chrom Tech’s HPLC solvent waste containment kits provide an efficient, compliant, and cost-effective way to safeguard your lab. Protect personnel, prevent spills, and maintain full EPA compliance with Chrom Tech’s reliable safety solutions.
Frequently Asked Questions About HPLC Solvent Waste Disposal
Why shouldn’t I use amber bottles for HPLC waste?
Amber bottles lack proper sealing and are prone to tipping, increasing the risk of spills and solvent vapor exposure. Closed-system waste containers are safer and EPA-compliant.
How often should I replace the activated carbon vapor filter?
Replace the vapor filter approximately every 3–6 months, or sooner if odors or discoloration appear. This ensures consistent vapor capture and lab air safety.
What happens if my waste container overflows?
Overflow is redirected through the vapor filter into the secondary containment basin. Always replace the vapor filter afterward to maintain safety and performance.
Are Chrom Tech waste kits compatible with all HPLC systems?
Yes. Chrom Tech waste containment kits include universal fittings and a 6-port manifold, compatible with nearly all HPLC instrument configurations.
Does Chrom Tech offer other lab safety products?
Absolutely. Chrom Tech supplies Justrite safety cabinets, secondary spill basins, vapor filters, and other laboratory safety solutions to keep your workspace compliant and protected.