Agilent HPLC Columns

ZORBAX, Poroshell, Polaris & Pursuit HPLC Columns

Chrom Tech supplies a complete portfolio of Agilent HPLC columns for small-molecule analysis, including superficially porous InfinityLab Poroshell 120 columns and fully porous ZORBAX, Polaris, and Pursuit series. Together, these families support an exceptionally wide range of separation modes, selectivity options, and analytical workflows.

Reversed-phase LC remains the dominant technique for small-molecule separations, and choosing the right phase is critical for achieving consistent retention, resolution, and peak shape. Agilent’s column platforms deliver industry-leading reproducibility and efficiency, with multiple bonded phases, pore sizes, and particle technologies engineered for both HPLC and UHPLC performance.

For expert guidance in selecting the ideal Agilent column for your application, contact Chrom Tech to connect with our chromatography specialists.

Explore HPLC Columns
Shop HPLC Columns
Explore all column families, modes, applications, and resources in the full pillar guide.

Agilent HPLC Column Categories

Explore genuine Agilent HPLC Columns

Product List

1
2
3
4
1
2
3
4
1
2
3
4
1
2
3
4
1
2
3
4
1
2
3
4
1
2
3
4
1
2
3
4
1
2
3
4
1
2
3
4
1
2
3
4
1
2
3
4
1
2
3
4
SKU Name LC Column Phase Particle Size Inner Diameter (ID) Length
SKU
650750-408
Name
650750-408 - Poroshell 120 PFP, 2.1 x 250 mm, 4um
LC Column Phase
PFP
Particle Size
4 um
Inner Diameter (ID)
2.1 mm
Length
250 mm
SKU
5185-5923
Name
5185-5923 - Extend Guard, 1.0x17mm, 5um, 3/pk
LC Column Phase
Extend-C18
Particle Size
5 um
Inner Diameter (ID)
1 mm
Length
17 mm
SKU
5185-5922
Name
5185-5922 - Bonus-RP Guard, 1.0x17mm, 5um
LC Column Phase
Bonus-RP
Particle Size
5 um
Inner Diameter (ID)
1 mm
Length
17 mm
SKU
5185-5921
Name
5185-5921 - Eclipse XDB Guard, 1.0x17mm, 5um
LC Column Phase
Eclipse XDB-C18
Particle Size
5 um
Inner Diameter (ID)
1 mm
Length
17 mm
SKU
5185-5920
Name
5185-5920 - StableBond Guard, 1.0x17mm, 5um, 3/pk
LC Column Phase
SB-C18
Particle Size
5 um
Inner Diameter (ID)
1 mm
Length
17 mm
SKU
5064-8253
Name
5064-8253 - ZORBAX SB C18 5u guard 35 x 0.3mm
LC Column Phase
SB-C18
Particle Size
5 um
Inner Diameter (ID)
0.3 mm
Length
35 mm
SKU
5064-8298
Name
5064-8298 - ZORBAX XDB C18 RR 3.5u 35 x 0.5mm
LC Column Phase
Eclipse XDB-C18
Particle Size
3.5 um
Inner Diameter (ID)
0.5 mm
Length
35 mm
SKU
5064-8288
Name
5064-8288 - ZORBAX XDB C18 RR 3.5u 150 x 0.5mm
LC Column Phase
Eclipse XDB-C18
Particle Size
3.5 um
Inner Diameter (ID)
0.5 mm
Length
150 mm
SKU
5064-8262
Name
5064-8262 - ZORBAX SB C18 RR 3.5 u 150 x 0.5mm
LC Column Phase
SB-C18
Particle Size
3.5 um
Inner Diameter (ID)
0.5 mm
Length
150 mm
SKU
5064-8261
Name
5064-8261 - ZORBAX SB C18 RR 3.5u 150 x 0.3 mm
LC Column Phase
SB-C18
Particle Size
3.5 um
Inner Diameter (ID)
0.3 mm
Length
150 mm
SKU
5064-8260
Name
5064-8260 - ZORBAX SB C18 RR 3.5u, 35 x 0.5 mm
LC Column Phase
SB-C18
Particle Size
3.5 um
Inner Diameter (ID)
0.5 mm
Length
35 mm
SKU
5064-8256
Name
5064-8256 - ZORBAX SB C18 5u 150 x 0.5mm
LC Column Phase
SB-C18
Particle Size
5 um
Inner Diameter (ID)
0.5 mm
Length
150 mm
Key Definitions ▸
Reversed-Phase Chromatography (RP)
The most widely used LC mode. Utilizes non-polar stationary phases such as C18 or C8 and polar mobile phases. Ideal for small molecules requiring predictable retention and high reproducibility.
Superficially Porous Particles (SPP)
Also called “core-shell” particles. Used in Agilent Poroshell 120 columns to deliver UHPLC-grade efficiency with reduced back-pressure, enabling faster and higher-resolution separations.
Fully Porous Particles (FPP)
Traditional particle design used in Agilent ZORBAX, Polaris, and Pursuit columns. Offers broad selectivity, robust durability, and compatibility across classic and modern LC methods.
Particle Size
A key factor influencing efficiency, pressure, and resolution. Smaller particles (≤2–3 µm) deliver UHPLC-level performance, while 3.5–5 µm particles are ideal for standard HPLC systems.
Stationary Phase
The bonded surface chemistry—such as C18, C8, Phenyl-Hexyl, CN, or Bonus-RP—that determines retention, selectivity, and overall chromatographic behavior.
Frequently Asked Questions ▸
What types of Agilent HPLC columns does Chrom Tech offer?
Chrom Tech offers the full Agilent portfolio, including InfinityLab Poroshell 120, ZORBAX Eclipse Plus and XDB, StableBond, Extend-C18, Bonus-RP, Polaris, and Pursuit XRs columns—optimized for small-molecule separations.
What is the difference between Poroshell and ZORBAX columns?
Poroshell 120 columns use superficially porous particles for higher efficiency and faster separations, while ZORBAX columns are fully porous and offer broad selectivity across many stationary phases and applications.
Can these Agilent columns be used for UHPLC?
Yes. Many Agilent columns—including Poroshell 120, ZORBAX Eclipse Plus, and Pursuit XRs—are rated for UHPLC platforms and deliver high efficiency and excellent resolution at elevated pressures.