Agilent HPLC Columns

ZORBAX, Poroshell, Polaris & Pursuit HPLC Columns

Chrom Tech supplies a complete portfolio of Agilent HPLC columns for small-molecule analysis, including superficially porous InfinityLab Poroshell 120 columns and fully porous ZORBAX, Polaris, and Pursuit series. Together, these families support an exceptionally wide range of separation modes, selectivity options, and analytical workflows.

Reversed-phase LC remains the dominant technique for small-molecule separations, and choosing the right phase is critical for achieving consistent retention, resolution, and peak shape. Agilent’s column platforms deliver industry-leading reproducibility and efficiency, with multiple bonded phases, pore sizes, and particle technologies engineered for both HPLC and UHPLC performance.

For expert guidance in selecting the ideal Agilent column for your application, contact Chrom Tech to connect with our chromatography specialists.

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Key Definitions ▸

Reversed-Phase Chromatography (RP)

The most widely used LC mode. Utilizes non-polar stationary phases such as C18 or C8 and polar mobile phases. Ideal for small molecules requiring predictable retention and high reproducibility.

Superficially Porous Particles (SPP)

Also called “core-shell” particles. Used in Agilent Poroshell 120 columns to deliver UHPLC-grade efficiency with reduced back-pressure, enabling faster and higher-resolution separations.

Fully Porous Particles (FPP)

Traditional particle design used in Agilent ZORBAX, Polaris, and Pursuit columns. Offers broad selectivity, robust durability, and compatibility across classic and modern LC methods.

Particle Size

A key factor influencing efficiency, pressure, and resolution. Smaller particles (≤2–3 µm) deliver UHPLC-level performance, while 3.5–5 µm particles are ideal for standard HPLC systems.

Stationary Phase

The bonded surface chemistry—such as C18, C8, Phenyl-Hexyl, CN, or Bonus-RP—that determines retention, selectivity, and overall chromatographic behavior.

Frequently Asked Questions ▸

What types of Agilent HPLC columns does Chrom Tech offer?

Chrom Tech offers the full Agilent portfolio, including InfinityLab Poroshell 120, ZORBAX Eclipse Plus and XDB, StableBond, Extend-C18, Bonus-RP, Polaris, and Pursuit XRs columns—optimized for small-molecule separations.

What is the difference between Poroshell and ZORBAX columns?

Poroshell 120 columns use superficially porous particles for higher efficiency and faster separations, while ZORBAX columns are fully porous and offer broad selectivity across many stationary phases and applications.

Can these Agilent columns be used for UHPLC?

Yes. Many Agilent columns—including Poroshell 120, ZORBAX Eclipse Plus, and Pursuit XRs—are rated for UHPLC platforms and deliver high efficiency and excellent resolution at elevated pressures.

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SKU Name LC Column Phase Particle Size Inner Diameter (ID) Length
SKU
820950-914
Name
820950-914 - Rx-C18 Guard Cartridges 4.6 x 12.5 4/PK
LC Column Phase
Rx-C18
Particle Size
5 um
Inner Diameter (ID)
4.6 mm
Length
13 mm
SKU
821125-933
Name
821125-933 - SB-Aq, 2.1 x 12.5mm, Guard Cartridge 5um 4/PK
LC Column Phase
SB-Aq
Particle Size
5 um
Inner Diameter (ID)
2.1 mm
Length
12.5 mm
SKU
820444-901
Name
820444-901 - PrepHT Guard Hardware Kit
LC Column Phase
Particle Size
Inner Diameter (ID)
Length
SKU
820950-913
Name
820950-913 - Rx-C8 Guard Cartridges 4.6 x 12.5 4/PK
LC Column Phase
Rx-C8
Particle Size
5 um
Inner Diameter (ID)
4.6 mm
Length
13 mm
SKU
820400-901
Name
820400-901 - PrepHT,Hardware,21.2mm Crt.End Ftg 2/PK
LC Column Phase
Particle Size
Inner Diameter (ID)
21.2 mm
Length
SKU
821125-930
Name
821125-930 - Extend-C18, Guard, 5u, 2.1x12.5mm 4PK
LC Column Phase
Extend-C18
Particle Size
5 um
Inner Diameter (ID)
2.1 mm
Length
13 mm
SKU
820212-933
Name
820212-933 - PrepHT,Zorbax,SB-Aq,Grd Crt,5um,2/PK
LC Column Phase
SB-Aq
Particle Size
5 um
Inner Diameter (ID)
16 mm
Length
10 mm
SKU
821125-928
Name
821125-928 - Bonus-RP NB Guard Cart 5u 2.1x12.5mm 4PK
LC Column Phase
Bonus-RP
Particle Size
5 um
Inner Diameter (ID)
2.1 mm
Length
13 mm
SKU
820950-908
Name
820950-908 - NH2 Guard Cartridges 4.6 x 12.5 4/PK
LC Column Phase
Original NH2
Particle Size
5 um
Inner Diameter (ID)
4.6 mm
Length
13 mm
SKU
820212-930
Name
820212-930 - PrepHT,Zorbax,Extend,Grd Crt,5um,2/PK
LC Column Phase
Extend-C18
Particle Size
5 um
Inner Diameter (ID)
16 mm
Length
8 mm
SKU
821125-926
Name
821125-926 - Eclipse XDB-C8 2.1x12.5,5u Grd Car 4/PK
LC Column Phase
Eclipse XDB-C8
Particle Size
5 um
Inner Diameter (ID)
2.1 mm
Length
13 mm
SKU
820212-928
Name
820212-928 - PrepHT,Zorbax,Bonus-RP,Grd Crt,5um,2/PK
LC Column Phase
Bonus-RP
Particle Size
5 um
Inner Diameter (ID)
17 mm
Length
8 mm