Rxi-624Sil MS

Rxi-624Sil MS column

Restek Rxi-624Sil MS GC Columns

Restek Rxi-624Sil MS GC columns are engineered for superior performance in the analysis of volatile organic compounds (VOCs) and residual solvents, offering a highly selective and robust alternative to traditional 624-type stationary phases. Featuring a mid-polarity Crossbond® silarylene-reinforced phase, these columns deliver exceptional thermal stability, inertness, and reproducibility—making them a top choice for pharmaceutical, environmental, and industrial laboratories.

With maximum operating temperatures of 300–320 °C, Rxi-624Sil MS columns support fast, efficient elution of high-boiling compounds while maintaining the very low bleed levels required for sensitive GC-MS workflows. The enhanced inertness of the deactivation chemistry ensures sharp, symmetrical peak shapes for both polar and reactive analytes, minimizing adsorption and improving quantitation accuracy across a wide range of VOCs.

Equivalent to USP phase G43, Rxi-624Sil MS columns provide the selectivity required for critical applications such as USP <467> residual solvent testing and EPA VOC analysis. Their outstanding lot-to-lot consistency also supports validated and regulated methods where reproducibility is essential.

As an authorized distributor of Restek products, Chrom Tech supplies Rxi-624Sil MS columns as a high-performance alternative to Agilent DB-624, Agilent VF-624ms, Agilent CP-Select 624 CB, SGE BP624, and Machery-Nagel Optima 624 LB columns—providing laboratories with reliable, MS-grade selectivity, inertness, and thermal stability for demanding VOC and residual-solvent workflows.
Key Definitions ▸
Crossbond® Silarylene Phase
A mid-polarity stationary phase reinforced with silarylene groups that improves thermal stability, reduces bleed, and enhances performance in high-temperature GC and GC-MS applications.
USP Phase G43
A compendial classification for 6% cyanopropyl/phenyl, 94% dimethylpolysiloxane phases used for residual solvent testing. Rxi-624Sil MS columns provide equivalent selectivity for USP <467> analysis.
Low Bleed
The minimized release of stationary-phase components at elevated temperatures. Low bleed improves GC-MS sensitivity, reduces background noise, and enhances mass-spectral clarity.
Residual Solvent Analysis
The detection and quantitation of volatile organic solvents left over from pharmaceutical manufacturing processes. Rxi-624Sil MS is highly selective for these compounds and supports regulatory methods such as USP <467>.
Column-to-Column Reproducibility
The capability of a stationary phase to maintain consistent performance across multiple manufacturing lots—critical for validated and regulated analytical workflows.
Frequently Asked Questions ▸
What applications are Rxi-624Sil MS columns best suited for?
Rxi-624Sil MS is ideal for volatile organic compound (VOC) analysis, residual solvent testing, environmental VOC methods, pharmaceutical QC, and GC-MS workflows requiring clean baselines and mid-polarity selectivity.
Is Rxi-624Sil MS equivalent to other 624-type GC columns?
Yes. It provides equivalent selectivity to Agilent DB-624, VF-624ms, CP-Select 624 CB, SGE BP624, and Optima 624 LB columns, making method transfer straightforward.
Can Rxi-624Sil MS be used for USP <467> residual solvent testing?
Yes. As a USP G43-equivalent phase, Rxi-624Sil MS is widely used for Class 1, 2, and 3 residual solvent analysis in pharmaceutical products.
Why choose a silarylene-reinforced phase for VOC analysis?
Silarylene reinforcement improves high-temperature robustness and reduces column bleed, resulting in cleaner mass spectra and more accurate quantitation—especially important for trace VOCs and pharmaceutical solvents.