Rxi-1301Sil MS

Rxi-1301Sil MS column

Restek Rxi-1301Sil MS GC Columns

Restek Rxi-1301Sil MS GC columns are engineered for superior inertness and outstanding performance in the analysis of volatile and semi-volatile polar compounds. Featuring a stabilized 6% cyanopropylphenyl / 94% dimethyl polysiloxane stationary phase, these columns provide enhanced selectivity and dramatically improved peak shapes for oxygenates, polar VOCs, residual solvents, and other reactive species that typically exhibit poor chromatography on conventional 1301 phases.

The advanced Sil-deactivation technology used in Rxi-1301Sil MS columns significantly reduces analyte adsorption, enabling high-sensitivity quantitation across a wide range of GC and GC-MS applications. Ultra-low column bleed ensures cleaner backgrounds, improved signal-to-noise ratios, and more reliable mass-spectral identification—even under rigorous temperature programming.

As an authorized distributor of Restek products, Chrom Tech provides the full range of Rxi-1301Sil MS dimensions to support environmental testing (EPA methods), pharmaceutical impurity/solvent analysis (USP <467> and ICH workflows), food and flavor applications, industrial chemical monitoring, and forensic laboratories. These columns deliver the selectivity of a traditional 1301 phase with modern deactivation performance that minimizes downtime, increases method robustness, and ensures reproducible, high-quality results across instruments and laboratories.
Key Definitions ▸
1301 Phase Chemistry
A mid-polar stationary phase composed of approximately 6% cyanopropylphenyl and 94% dimethylpolysiloxane, widely used for separating oxygenates, polar VOCs, and industrial solvents. The Rxi-1301Sil MS version enhances this selectivity with improved inertness.
Sil-Deactivation Technology
Restek’s proprietary deactivation process that dramatically reduces surface activity inside the column, improving peak shape and recovery for polar, reactive, and adsorptive analytes. It is a key performance advantage of Rxi-1301Sil MS over conventional 1301 phases.
Ultra-Low Bleed
The minimized release of stationary-phase components during high-temperature analysis. Ultra-low bleed provides cleaner baselines, increased sensitivity, and more accurate mass-spectral identification—especially crucial for GC-MS workflows.
Oxygenates
Organic compounds containing oxygen (e.g., alcohols, ethers, ketones) that can be difficult to analyze due to their polarity and reactivity. The Rxi-1301Sil MS phase provides enhanced retention and improved peak shapes for these analytes.
Residual Solvent Analysis (USP <467>)
A pharmaceutical method for quantifying residual solvents in active ingredients and finished products. Rxi-1301Sil MS columns provide the improved inertness, peak shape, and sensitivity needed for accurate Class 1, 2, and 3 solvent analysis.
Frequently Asked Questions ▸
What types of compounds are best analyzed using the Rxi-1301Sil MS column?
Rxi-1301Sil MS columns excel in the analysis of oxygenates, polar VOCs, industrial solvents, and reactive compounds such as aldehydes, ketones, and amines. The enhanced inertness provides significantly improved peak shapes and sensitivity for these challenging analytes.
Is the Rxi-1301Sil MS compatible with GC-MS workflows?
Yes. The ultra-low bleed characteristics of the Rxi-1301Sil MS make it ideal for GC-MS applications requiring high sensitivity, stable baselines, and accurate mass-spectral identification—even under aggressive temperature programs.
How does the Rxi-1301Sil MS compare to a traditional 1301 GC column?
While maintaining the same selectivity as traditional 1301 phases, the Rxi-1301Sil MS delivers superior inertness, lower bleed, and more consistent performance. This results in better peak shapes for reactive analytes and improved long-term method stability.
What applications commonly use the Rxi-1301Sil MS column?
Environmental VOC methods (EPA), pharmaceutical solvent testing (USP <467>), food and flavor profiling, industrial chemical analysis, and forensic toxicology all benefit from the enhanced selectivity, inertness, and thermal stability of Rxi-1301Sil MS GC columns.