Quantitative Analysis of 58 Antipsychotics and Antidepressants in Human Urine

The prevalence of mental health disorders continues to strain the well-being of individuals globally. As these conditions gain greater recognition in contemporary society, the use of prescribed antipsychotics (APs) and antidepressants (ADs) continues to rise. According to the CDC, over a fifteen-year time span, the use of antidepressants has increased nearly 65%.

These medications are prescribed for various psychiatric conditions, including schizophrenia, bipolar disorder, dysthymia, social anxiety disorder, obsessive-compulsive disorder, and chronic pain. In forensic investigations, the detection of these drugs is essential due to their potential for abuse, as it plays a crucial role in identifying their involvement in cases of intoxication and suicides. 

In the clinical setting, analysis of APs and Ads in blood or urine is necessary to ensure suitable therapeutic concentration and to monitor patient compliance. It has been reported that the patient’s adherence to prescribed APs is quite low, and thus new clinical recommendations have been released regarding when and how to use urine testing procedures to help monitor adherence. By combining a simple sample preparation procedure and a fast chromatographic elution with the Raptor Biphenyl column, a highly specific and accurate method was established for simultaneous measurement of 28 Antipsychotics and 30 Antidepressant drugs in human urine.

Chrom Tech is a Minnesota-based, worldwide distributor of chromatography instrumentation and supplies and mass spectrometry supplies. We carry vials, well plates, syringe filters, solvent waste containers and all other critical chromatography and spectrometry supplies. Contact Chrom Tech  to become your preferred supplier of chromatography and mass spectrometry supplies.