Life Sciences

Life Sciences column

Agilent Life Sciences GC Columns

Agilent Life Sciences GC columns are purpose-engineered to meet the stringent analytical demands of pharmaceutical quality control, biomolecular research, clinical testing, and regulated life-science workflows. These columns deliver exceptional sensitivity, reproducibility, and chemical inertness—critical for analyzing trace-level impurities, solvents, metabolites, degradation products, and complex biological matrices with confidence and precision.

The portfolio includes a range of application-specific phases that optimize separation performance for life-science targets:

DB-ALC1 and DB-ALC2 These highly optimized ethanol and methanol analysis columns are engineered for rapid, stable, and reproducible separation of alcohols in biological matrices and fermentation broths. Their selectivity enables accurate quantitation of high and low alcohol levels in pharmaceutical, clinical, and bioproduction workflows.

DB-5ms EVDX Designed for extended-volatility range performance, DB-5ms EVDX provides robust separation of complex analyte mixtures containing both volatile and semi-volatile components. Its ultra-low bleed characteristics support highly sensitive mass-spectrometric detection, ideal for trace impurities, extractables, and leachables in pharma and biologics.

DB-Select 624 UI 467 Built for USP <467> residual solvent analysis, this Ultra Inert 624 phase delivers excellent peak shape and resolution for Class 1, 2, and 3 solvents with high sensitivity and batch-to-batch consistency. It supports fast, rugged workflows for pharmaceutical release testing and regulatory compliance.

HP-Fast Residual Solvent An accelerated-analysis column designed specifically for rapid residual solvent determination, enabling fast GC cycles without sacrificing resolution. HP-Fast Residual Solvent allows laboratories to increase sample throughput while maintaining full USP <467> compliance—ideal for high-volume QC environments.

Together, these specialized GC columns provide laboratories with the precision, robustness, and efficiency required to support life-science applications ranging from pharmaceutical development and GMP release testing to metabolite profiling and bioprocess monitoring. As an authorized distributor of Agilent GC supplies, Chrom Tech delivers these columns with the technical expertise and support needed to optimize your analytical workflows.
Key Definitions ▸
USP <467> Residual Solvents
A pharmaceutical quality-control test that quantifies Class 1, 2, and 3 residual solvents. GC columns such as DB-Select 624 UI 467 and HP-Fast Residual Solvent are engineered to meet the sensitivity, selectivity, and resolution requirements of this method.
Extended Volatility Range (EVDX)
A column design optimized to separate both volatile and semivolatile compounds in a single run. The DB-5ms EVDX phase provides ultra-low bleed performance for highly sensitive MS detection of impurities, extractables, and leachables.
Ultra Inert (UI) Deactivation
Agilent’s advanced deactivation technology that improves peak shape, minimizes adsorption, and enhances sensitivity—critical for life-science analytes such as residual solvents, metabolites, and polar impurities.
DB-ALC1 / DB-ALC2 Alcohol Analysis Columns
Application-specific GC columns designed for ethanol and methanol quantitation in biological matrices, fermentation broths, and pharmaceutical workflows. They deliver superior peak shape, reproducibility, and ruggedness across a wide concentration range.
Frequently Asked Questions ▸
Which GC columns are best for USP <467> residual solvent testing?
Agilent DB-Select 624 UI 467 and HP-Fast Residual Solvent columns are specifically engineered for USP <467>, providing the selectivity, sensitivity, and peak shape needed for Class 1, 2, and 3 residual solvent quantitation in pharmaceutical workflows.
What advantages does the DB-5ms EVDX column offer for life-science applications?
DB-5ms EVDX provides an extended volatility range, allowing simultaneous analysis of volatile and semivolatile compounds. Its ultra-low bleed performance supports highly sensitive MS detection required for impurities, extractables, and leachables.
When should DB-ALC1 or DB-ALC2 be used instead of a general-purpose column?
DB-ALC1 and DB-ALC2 are optimized specifically for ethanol and methanol determination in biological and pharmaceutical matrices. They provide superior selectivity and reproducibility for alcohol quantitation compared to general-purpose phases.
How do I choose between DB-Select 624 UI 467 and HP-Fast Residual Solvent?
DB-Select 624 UI 467 is ideal for traditional USP <467> workflows requiring full resolution and maximum inertness. HP-Fast Residual Solvent is preferred when faster cycle times are needed without compromising method compliance, making it ideal for high-throughput QC labs.