HP-Fast Residual Solvent

HP-Fast Residual Solvent column

Agilent HP-Fast Residual Solvent GC Columns

Agilent HP-Fast Residual Solvent GC columns are engineered for rapid, compliant analysis of residual solvents in pharmaceutical ingredients and finished drug products. Built to support United States Pharmacopoeia (USP) Method 467 while dramatically shortening analysis time, HP-Fast columns deliver high-resolution separations in significantly faster runs, enabling laboratories to increase throughput without compromising accuracy or regulatory compliance.

Designed with optimized 624-type selectivity, HP-Fast Residual Solvent columns provide excellent separation of Class 1, Class 2, and Class 3 solvents, including challenging critical pairs that must be fully resolved for USP 467. Their superior inertness and low bleed characteristics enhance sensitivity for GC and GC/MS detection, improving signal-to-noise ratios and providing reliable quantitation across a broad range of pharmaceutical matrices.

HP-Fast columns are ideal for high-volume QC environments where cycle time reduction directly improves operational efficiency. Their stable coating, rugged performance, and consistent batch-to-batch reproducibility ensure long-lasting reliability, even under demanding conditions. By combining fast separations with precise USP-aligned selectivity, Agilent HP-Fast Residual Solvent GC columns offer a powerful solution for accelerated yet fully compliant residual solvent testing.
Key Definitions â–¸
HP-Fast Residual Solvent Columns
High-throughput GC columns engineered to accelerate USP <467> residual solvent analysis by delivering significantly shorter run times while maintaining USP-compliant selectivity and sensitivity for pharmaceutical quality control.
USP <467> Residual Solvents
A United States Pharmacopoeia method that classifies solvents into three groups (Class 1, 2, and 3) and defines the approved GC procedures for their identification and quantitation in APIs, excipients, and drug products.
624-Type Selectivity
A stationary phase composition typically containing 6% cyanopropylphenyl and 94% dimethylpolysiloxane, used for resolving a broad range of residual solvents. HP-Fast columns use optimized 624-like selectivity to maintain USP performance while enabling faster separations.
Cycle Time Reduction
The ability to complete full analytical runs in less time without loss of resolution or method compliance. HP-Fast Residual Solvent columns shorten total analysis time, increasing throughput for high-volume pharmaceutical QC laboratories.
Frequently Asked Questions â–¸
How do HP-Fast Residual Solvent columns differ from standard 624-type columns?
HP-Fast columns use optimized 624-type selectivity designed for dramatically shorter run times while preserving the critical separations required for USP <467>. They provide the same regulatory compliance with significantly increased throughput.
Are HP-Fast columns compliant with USP <467> requirements?
Yes. HP-Fast Residual Solvent columns meet the selectivity and resolution requirements of USP <467>, enabling compliant testing of Class 1, 2, and 3 residual solvents in pharmaceutical ingredients and finished products.
What advantages do HP-Fast columns offer for high-throughput laboratories?
HP-Fast columns significantly reduce analysis time while maintaining USP-compliant separations, allowing QC labs to process more samples per shift without sacrificing accuracy or sensitivity.
Are HP-Fast Residual Solvent columns compatible with GC/MS workflows?
Yes. Their low bleed characteristics and optimized inertness make them ideal for GC/MS, improving sensitivity and reducing background noise for trace-level residual solvent quantitation.