Friction Seals & Cap Mats

96 Well Plate Covers and Mats

Protect your samples throughout storage, transport, incubation, and analytical workflows with Chrom Tech’s high-performance 96-well plate covers and sealing mats. Engineered for dependable sealing and long-term durability, these covers fit securely over each well to reduce evaporation, prevent cross-contamination, and maintain the integrity of sensitive biological or analytical samples.

Choose from friction-fit covers for rapid manual closure or pierceable PTFE/silicone cap mats designed for robotic autosamplers, chromatography workflows, and high-throughput screening. Each cover is molded to match standard 96-well plate geometry, ensuring a uniform seal across all wells—critical for consistent assay performance.

  • Available in friction-seal and pierceable PTFE/silicone configurations
  • Custom-molded designs provide a secure, leak-resistant fit across every well
  • PTFE and silicone sealing materials offer broad chemical and solvent compatibility
  • Ideal for high-throughput screening, autosampler workflows, and long-term sample protection
  • Offered in multiple layouts and materials to match standard 96-well microplate formats

Chrom Tech’s sealing mats provide reliable, repeatable sealing for both routine and demanding laboratory applications— offering an excellent balance of performance, chemical resistance, and value. Whether you’re preparing analytical samples, protecting biological assays, or supporting automated liquid handling, these covers ensure consistent, contamination-free results.

For assistance selecting the optimal cover or mat for your plate format or workflow, please contact our technical support team .

Looking for More 96-Well Plate Options?

View the complete lineup of polypropylene, deep-well, glass-insert, and specialty plate formats.

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Key Definitions ▸
Friction Seal Cover
A rigid or semi-flexible plate lid that snaps or presses into place over a 96-well microplate, providing quick manual sealing without tools or adhesives.
Pierceable Cap Mat
A PTFE/silicone composite sealing mat engineered to allow autosampler needles to penetrate each well while maintaining a tight, contamination-resistant seal.
Well Geometry
The shape, depth, and dimensions of each microplate well, which determine how securely a cover or mat fits and how effectively it prevents evaporation or leakage.
Evaporation Control
The ability of a sealing device to prevent sample loss due to evaporation during incubation, storage, or high-temperature workflows.
Chemical Compatibility
Resistance of sealing materials—such as silicone or PTFE—to solvents, reagents, and assay buffers used in analytical and biological workflows.
High-Throughput Screening (HTS)
Automated laboratory workflows that process large numbers of samples using robotic pipetting, requiring sealing mats that perform reliably under repeated puncture and handling.
Frequently Asked Questions ▸
What is the difference between a friction seal and a pierceable cap mat?
Friction seals are rigid covers that press into place for quick manual closure, while pierceable PTFE/silicone cap mats allow autosampler needles to penetrate each well for analytical workflows without removing the seal.
Are these covers compatible with standard SBS/ANSI 96-well plates?
Yes. All Chrom Tech covers and sealing mats are designed to fit standard SBS/ANSI 96-well microplates, ensuring compatibility with common plate brands and dimensions.
Do pierceable mats reduce sample evaporation during incubation?
Yes. PTFE/silicone mats provide an excellent seal that minimizes evaporation and cross-contamination, even during extended incubation or thermal cycling.
Are these mats suitable for autosampler injection workflows?
Yes. Pierceable PTFE/silicone mats are specifically designed for repeated needle penetration and are ideal for LC/MS autosamplers and high-throughput analytical workflows.
Do the covers withstand chemicals used in chromatography sample prep?
Yes. Silicone and PTFE/silicone materials offer excellent resistance to common reagents, solvents, and buffers used in biological and chromatography applications.