DB-Select 624 UI for <467>

DB-Select 624 UI for <467> column

Agilent DB-Select 624 UI 467 GC Columns

Agilent J&W DB-Select 624 UI 467 GC columns are engineered specifically to meet the rigorous requirements of United States Pharmacopoeia (USP) Method 467 for the determination of residual solvents in active pharmaceutical ingredients (APIs). Built on the proven 6% cyanopropyl/94% dimethylpolysiloxane selectivity equivalent to USP phase G43, this Ultra Inert (UI) version provides dramatically improved inertness, delivering superior peak shape and enhanced sensitivity for even the most reactive Class 1, Class 2, and Class 3 solvents.

DB-Select 624 UI 467 columns are optimized for the resolution of all critical analyte pairs defined in USP 467, ensuring tight, reproducible separations that support both qualitative identification and quantitative accuracy. Their high thermal stability, low bleed performance, and precision-deactivated surfaces maximize signal-to-noise ratios in GC and GC/MS workflows, making them ideal for routine pharmaceutical quality control and regulatory compliance testing.

Designed for robustness and consistency across batches, every DB-Select 624 UI 467 column is tested against stringent performance criteria to ensure reliable retention, sharp peak symmetry, and repeatability from run to run. The result is a column that provides the confidence, sensitivity, and performance required for compliant USP 467 residual solvent analysis in modern pharmaceutical laboratories.
Key Definitions â–¸
USP <467> Residual Solvents
A regulatory method defining specific procedures and critical analyte pairs used to detect and quantify Class 1, Class 2, and Class 3 residual solvents in pharmaceutical ingredients and drug products. DB-Select 624 UI 467 columns are engineered for full compliance with this method.
Ultra Inert (UI) Deactivation
Agilent’s advanced chemical deactivation technology that minimizes adsorption and improves recovery of reactive residual solvents. UI deactivation enhances sensitivity, peak shape, and reproducibility in GC and GC/MS workflows.
Critical Solvent Pairs
Analyte combinations that must be fully resolved for a GC column to be compliant with USP 467. DB-Select 624 UI 467 columns are optimized to reliably separate these pairs, supporting accurate identification and quantitation.
USP Phase G43
A 6% cyanopropyl / 94% dimethylpolysiloxane stationary phase specification defined by the USP. DB-Select 624 UI 467 columns match this selectivity while incorporating UI-level inertness for higher sensitivity and improved method robustness.
Frequently Asked Questions â–¸
Why is DB-Select 624 UI 467 recommended for USP <467> residual solvent analysis?
This column provides the precise selectivity of USP phase G43 combined with Ultra Inert deactivation, enabling high sensitivity, excellent peak symmetry, and reliable resolution of all critical solvent pairs defined in USP <467>.
What types of samples are typically analyzed using DB-Select 624 UI 467?
The column is primarily used for active pharmaceutical ingredients (APIs), intermediates, excipients, and finished drug products that require residual solvent testing according to USP <467>.
Is the column suitable for both GC and GC/MS workflows?
Yes. Its low bleed characteristics and inert deactivation make it fully compatible with both GC and GC/MS system configurations, ensuring optimal performance and sensitivity for solvent identification and quantitation.
What advantages does Ultra Inert deactivation provide for USP <467> methods?
Ultra Inert deactivation minimizes active sites that can adsorb volatile or polar solvents, improving recovery, enhancing peak shape, and increasing sensitivity—especially important for reactive Class 2 solvents that may otherwise show poor performance.