DB-624 UI

DB-624 UI column

Agilent DB-624 UI GC Columns

Agilent J&W DB-624 Ultra Inert (UI) GC columns are engineered to deliver exceptional sensitivity, improved peak symmetry, and superior inertness for the analysis of volatile organic compounds (VOCs) across pharmaceutical, environmental, food safety, and industrial chemical applications. As the Ultra Inert evolution of the industry-standard DB-624 phase, DB-624 UI is specifically designed for GC and GC/MS workflows where trace-level VOC detection and accurate quantitation are essential.

Featuring a mid-polar stationary phase composition of 6% cyanopropyl/phenyl and 94% polydimethylsiloxane, equivalent to USP phase G43, DB-624 UI retains the proven selectivity of its predecessor while greatly enhancing performance for active and difficult VOCs. Agilent’s unique Ultra Inert deactivation process minimizes adsorption, reduces analyte breakdown, and produces sharper, more symmetrical peaks—even for compounds that traditionally exhibit broad or tailing behavior.

With significantly improved signal-to-noise levels and reduced background interference, DB-624 UI enables more reliable qualitative and quantitative analysis of complex VOC mixtures. As an authorized distributor of Agilent GC columns, Chrom Tech provides DB-624 UI as a high-performance solution for laboratories requiring maximum sensitivity, stability, and reproducibility in VOC analysis.
Key Definitions ▸
DB-624 UI
An Ultra Inert version of the classic DB-624 GC column, designed to deliver improved peak shape, lower adsorption, and higher sensitivity for volatile organic compounds in GC and GC/MS workflows.
Ultra Inert (UI) Deactivation
Agilent’s proprietary column deactivation technology that minimizes active sites in the GC column, improving recovery and peak symmetry for active, polar, and low-level VOCs while maintaining low bleed for GC/MS detection.
USP Phase G43
A United States Pharmacopeia classification for a 6% cyanopropylphenyl, 94% polydimethylsiloxane stationary phase. DB-624 UI meets this specification, ensuring compatibility with regulated pharmaceutical VOC methods.
6% Cyanopropyl/Phenyl – 94% Polydimethylsiloxane Phase
A mid-polar stationary phase blend providing strong retention and selectivity for alcohols, ketones, esters, halogenated solvents, and other VOCs. This is the standard 624-type phase used widely in EPA and pharmaceutical VOC testing.
Frequently Asked Questions ▸
How is DB-624 UI different from the standard DB-624 column?
DB-624 UI features Agilent’s Ultra Inert deactivation, which provides sharper peaks, reduced adsorption, and higher sensitivity for active VOCs. While both share the same 624 stationary phase and selectivity, the Ultra Inert version offers improved performance for GC/MS and trace-level VOC analysis.
Is DB-624 UI suitable for USP-regulated pharmaceutical VOC methods?
Yes. DB-624 UI is equivalent to USP phase G43, making it suitable for regulated pharmaceutical workflows requiring validated VOC analysis with precise retention behavior and strong inertness for active compounds.
What types of VOCs benefit most from the Ultra Inert deactivation?
Active and polar VOCs—including alcohols, organic acids, ketones, and aldehydes—show significantly better peak shape and recovery on DB-624 UI. The improved inertness reduces tailing and enhances signal-to-noise, making the column particularly valuable in GC/MS workflows.