CP-Sil 19 CB

Standard Polysiloxane GC Columns

Agilent CP-Sil 19 CB is a mid-polarity GC column engineered with a (14% cyanopropyl-phenyl)- methylpolysiloxane stationary phase. This unique column chemistry provides enhanced selectivity for compounds that are difficult to resolve on fully nonpolar phases, making CP-Sil 19 CB an excellent choice for complex mixtures requiring balanced dispersive and dipole–dipole interactions.

Designed for routine and regulated workflows, CP-Sil 19 CB is widely used in environmental, food safety, petrochemical, and specialty chemical applications. It provides superior separation of moderately polar analytes such as pesticides, herbicides, aromatic compounds, halogenated species, and trimethylsilyl (TMS) derivatives. The column’s mid-polarity profile helps reduce coelution and improves peak spacing in multi-component matrices.

Manufactured with Agilent’s high-precision bonding and crosslinking processes, CP-Sil 19 CB delivers outstanding thermal stability, extremely low bleed, and long-term retention reproducibility. Its rugged polyimide-coated tubing and chemically reinforced stationary phase allow solvent rinsing and repeated high-temperature cycling without degradation, ensuring reliable performance over extended column lifetimes.

CP-Sil 19 CB is also available in Agilent’s UltiMetal-treated hardware for maximum durability at elevated operating temperatures, making it suitable for demanding workflows involving aggressive or high-boiling analytes. This column is an ideal option for laboratories requiring consistent, selective, and efficient separations with the flexibility to support both GC and GC/MS analysis.

Key Definitions â–¸
(14% Cyanopropyl-Phenyl)-Methylpolysiloxane Phase
A stationary phase containing 14% cyanopropyl and phenyl functional groups integrated into a methylpolysiloxane backbone. This mid-polarity chemistry provides enhanced selectivity for analytes requiring more polarity than nonpolar phases can offer, but without the strong retention characteristic of highly polar phases.
Mid-Polarity GC Column
A GC column with balanced dispersive and dipole–dipole interactions, designed for improved separation of moderately polar analytes. Mid-polarity phases like CP-Sil 19 CB are ideal for environmental, food safety, and industrial methods with diverse analyte classes.
TMS Derivatives
Trimethylsilyl (TMS) derivatives are formed by reacting analytes with silylation reagents to improve volatility and thermal stability in GC. CP-Sil 19 CB provides enhanced resolution for TMS derivatives of sugars, organic acids, and structurally related compounds.
UltiMetal Treatment
A proprietary Agilent metal surface treatment that enhances chemical inertness and thermal durability of metal GC column hardware. UltiMetal columns support higher operating temperatures and deliver improved robustness in challenging applications.
Bonded and Crosslinked Construction
Indicates that the stationary phase is chemically bonded to the inner column wall and crosslinked for enhanced thermal stability. This allows solvent rinsing, reduces bleed, and ensures long-term reproducibility across demanding GC and GC/MS workflows.
Frequently Asked Questions â–¸
What types of applications is CP-Sil 19 CB best suited for?
CP-Sil 19 CB excels in environmental, food safety, petrochemical, and specialty chemical applications. Its mid-polarity phase provides strong separation for moderately polar compounds, including pesticides, halogenated species, TMS derivatives, and aromatic analytes.
Is CP-Sil 19 CB suitable for GC/MS?
Yes. Its bonded and crosslinked construction minimizes bleed and provides stable chromatographic performance at elevated temperatures, making it compatible with both GC and GC/MS workflows requiring sensitive detection and clean baselines.
How does CP-Sil 19 CB compare to CP-Sil 5 CB or DB-5–type columns?
CP-Sil 19 CB provides more polarity than CP-Sil 5 CB or DB-5–type columns, improving separation of moderately polar analytes. It resolves compounds that tend to overlap on nonpolar phases, making it better suited for complex mixtures requiring additional dipole– dipole interaction or aromatic selectivity.
What are the benefits of choosing an UltiMetal version of CP-Sil 19 CB?
UltiMetal-treated hardware enhances inertness and allows higher maximum operating temperatures. It is recommended for aggressive analytes, high-temperature methods, or rugged environments where increased durability and heat tolerance are essential.
Can CP-Sil 19 CB be solvent rinsed?
Yes. CP-Sil 19 CB is bonded and crosslinked, allowing solvent rinsing without damaging the stationary phase. This helps maintain performance in workflows involving dirty matrices or frequent sample injections.