CP-Chirasil-Dex CB

CP-Chirasil-Dex CB column

Agilent CP-Chirasil-Dex CB GC Columns

Agilent J&W CP-Chirasil-Dex CB GC columns feature β-cyclodextrin directly bonded to a dimethylpolysiloxane backbone, creating a highly uniform chiral stationary phase with exceptional stability and reproducibility. By chemically anchoring the cyclodextrin to the polymer matrix, CP-Chirasil-Dex CB prevents phase migration within the coating—a common issue in non-bonded chiral phases—resulting in homogeneous enantioselectivity across the entire column.

This direct-bonded architecture provides the highest resolution of enantiomeric isomers, delivering sharp, reproducible separations for chiral compounds across flavors, fragrances, specialty chemicals, pharmaceuticals, and environmental analyses. The enhanced structural stability also extends the usable lifetime of the β-cyclodextrin phase, maintaining consistent enantiomeric recognition and retention behavior even during long-term, high-throughput use.

CP-Chirasil-Dex CB supports elution of polar chiral analytes at relatively low temperatures, reducing thermal stress on thermally labile compounds and improving quantitation of delicate or trace-level isomers. Its compatibility with all common injection techniques—including split, splitless, on-column, and PTV—makes it a versatile and high-performance choice for laboratories requiring reliable, high-resolution chiral GC separations.
Key Definitions â–¸
CP-Chirasil-Dex CB
A chiral GC column featuring β-cyclodextrin directly bonded to a dimethylpolysiloxane polymer, providing homogeneous enantioselectivity, exceptional phase stability, and high-resolution separation of chiral isomers.
Direct-Bonded Cyclodextrin Phase
A GC stationary phase in which cyclodextrin molecules are chemically bonded to the polymer backbone. This prevents migration within the film, ensuring consistent enantiomeric selectivity and extending column lifetime.
Homogeneous Enantioselectivity
Uniform chiral recognition across the entire stationary phase, resulting in highly reproducible and efficient separations of enantiomeric isomers—even over long-term use.
Low-Temperature Elution of Polar Compounds
CP-Chirasil-Dex CB allows polar chiral analytes to elute at lower oven temperatures, reducing risk of thermal degradation and improving quantitation of delicate or thermally sensitive isomers.
Frequently Asked Questions â–¸
What makes CP-Chirasil-Dex CB different from non-bonded chiral GC phases?
Unlike non-bonded cyclodextrin phases, CP-Chirasil-Dex CB chemically bonds the cyclodextrin to the polymer backbone. This prevents phase migration, improves column lifetime, and delivers uniform enantioselectivity across the entire stationary phase—resulting in higher resolution and more stable separations.
What types of chiral compounds are best analyzed on CP-Chirasil-Dex CB?
The column is ideal for polar and thermally sensitive chiral analytes, including alcohols, esters, lactones, flavor and fragrance volatiles, and other compounds requiring low-temperature elution and high-resolution enantiomeric separation.
Why does CP-Chirasil-Dex CB improve column lifetime?
Because the cyclodextrin is chemically bonded to the dimethylpolysiloxane polymer, it cannot migrate within the film. This stabilizes enantioselectivity over time and reduces degradation, significantly extending the usable life of the β-cyclodextrin phase.
Is CP-Chirasil-Dex CB compatible with all injection techniques?
Yes. The bonded phase structure supports reliable performance with split, splitless, on-column, and PTV injection techniques. Its stability and low bleed also support sensitive detection modes across a variety of chiral GC workflows.