Captiva ND

Agilent Captiva ND Sample Preparation

Agilent Captiva ND (Non-Drip) devices are designed to simplify automated sample preparation by preventing premature solvent flow until vacuum is applied. This non-drip architecture supports clean, controlled processing while enabling seamless integration into automated and semi-automated laboratory workflows.

A proprietary dual-depth filtration design delivers exceptional flow performance by reducing membrane clogging and minimizing sample loss. Combined with efficient protein precipitation using acetonitrile or methanol, Captiva ND produces MS-ready samples in a fraction of traditional preparation time—often as little as one-fifth—helping labs accelerate throughput without compromising data quality.

Key Benefits

  • Non-drip design resists organic solvent flow until vacuum is applied, supporting easy automation
  • Dual-depth filter construction prevents plugged membranes and lost samples
  • Rapid protein removal using acetonitrile or methanol for MS-suitable extracts
  • Delivers faster sample preparation compared to conventional filtration methods
  • Available in multiple pore sizes for flexibility across solvents and applications

Captiva ND products are well suited for bioanalytical, pharmaceutical, and clinical workflows where speed, reproducibility, and automation compatibility are essential. Chrom Tech supplies Captiva ND solutions as part of a complete sample preparation portfolio to help laboratories achieve consistent, high-confidence analytical results.

PART NO DESCRIPTION QTY
CAPTIVA ND 96-WELL FILTER PLATES
A5969002 Captiva ND plate, 0.2 µm, polypropylene — recommended for both methanol and acetonitrile 5/pk
A5969045 Captiva ND plate, 0.45 µm, polypropylene — suitable for acetonitrile only 5/pk
Key Definitions ▶
Captiva ND (Non-Drip)
A sample preparation design that prevents organic solvents from flowing through the device until vacuum is applied, enabling controlled, automation-friendly processing.
Dual-Depth Filter
A layered filtration structure that promotes high flow while reducing membrane clogging, helping prevent sample loss during protein precipitation and cleanup.
Protein Precipitation
A cleanup technique that uses organic solvents such as acetonitrile or methanol to remove proteins from samples, producing clarified extracts suitable for mass spectrometry analysis.
MS-Ready Samples
Processed samples that are sufficiently clean for direct injection into LC-MS systems, minimizing ion suppression and improving analytical reliability.
Pore Size
The nominal opening of the filtration membrane, available in multiple options to balance flow rate and particulate retention across different solvents and applications.
Frequently Asked Questions ▶
What is Agilent Captiva ND used for?
Captiva ND devices are used for rapid protein precipitation and sample cleanup, producing MS-ready extracts while supporting automated and semi-automated laboratory workflows.
What does “Non-Drip” mean?
Non-Drip refers to a design that prevents organic solvents from flowing through the device until vacuum is applied, allowing controlled processing and easier automation.
Which solvents are compatible with Captiva ND?
Captiva ND supports common protein precipitation solvents such as acetonitrile and methanol, enabling efficient cleanup for LC-MS workflows.
How does the dual-depth filter improve performance?
The dual-depth filter structure promotes high flow while reducing membrane clogging, helping prevent sample loss and maintaining consistent extraction across wells or cartridges.
Are Captiva ND products compatible with automation?
Yes. Captiva ND devices are designed for use with vacuum manifolds and automated liquid handling systems, making them ideal for high-throughput bioanalytical workflows.