Captiva EMR-Lipid

Agilent Captiva EMR-Lipid Sample Preparation

Agilent Captiva Enhanced Matrix Removal (EMR)-Lipid products are engineered to deliver highly selective lipid removal while preserving target analytes—making them ideal for complex food, biological, and environmental matrices. This advanced cleanup technology minimizes matrix effects and supports reliable quantitative results in LC-MS and GC-MS workflows.

Captiva EMR-Lipid removes lipids through a proprietary combination of size exclusion and hydrophobic interaction, efficiently trapping fats and phospholipids that commonly cause ion suppression. The result is cleaner extracts, improved signal response, and enhanced method robustness without sacrificing analyte recovery.

Key Benefits

  • Highly selective lipid and matrix removal without analyte loss
  • Reduces ion suppression for improved mass spectrometry sensitivity
  • Uses size exclusion and hydrophobic interaction for efficient cleanup
  • Delivers cleaner extracts from high-fat and complex samples
  • Supports faster, more reproducible sample preparation workflows

Captiva EMR-Lipid is well suited for pesticide residue testing, food safety analysis, clinical research, and bioanalytical applications where lipid interference can compromise data quality. Chrom Tech offers Captiva EMR-Lipid solutions as part of a complete sample preparation workflow to help labs achieve consistent, high-confidence results.

Key Definitions â–¶
EMR-Lipid (Enhanced Matrix Removal – Lipid)
A selective cleanup technology designed to remove lipids and fatty matrix components from samples while preserving target analytes for downstream analysis.
Matrix Effects
Interferences caused by co-extracted sample components—such as lipids—that can suppress or enhance analyte signals, impacting quantitative accuracy in mass spectrometry.
Size Exclusion
A separation mechanism that removes larger molecules, such as lipids, based on physical size while allowing smaller analytes to pass through for analysis.
Hydrophobic Interaction
A selective binding process that captures non-polar lipid molecules, helping reduce fat content and improve extract cleanliness.
Ion Suppression
A reduction in analyte signal caused by co-eluting matrix components, commonly lipids, that compete during ionization in LC-MS workflows.
Frequently Asked Questions â–¶
What is Captiva EMR-Lipid used for?
Captiva EMR-Lipid is used to selectively remove lipids and fatty matrix components during sample preparation, producing cleaner extracts for LC-MS and GC-MS analysis while preserving target analytes.
How does EMR-Lipid remove lipids?
Lipids are removed through a combination of size exclusion and hydrophobic interaction, which traps fats and phospholipids while allowing smaller analytes to pass through.
Does EMR-Lipid affect analyte recovery?
No. Captiva EMR-Lipid is engineered to provide highly selective lipid removal while maintaining excellent analyte recovery, helping ensure accurate quantitative results.
What types of samples benefit most from EMR-Lipid?
EMR-Lipid is ideal for high-fat or complex matrices such as food samples, biological fluids, tissue extracts, and environmental samples where lipid interference can impact data quality.
How does EMR-Lipid improve LC-MS performance?
By removing lipids that commonly cause ion suppression, EMR-Lipid delivers cleaner extracts, stronger analyte signals, and improved method robustness in mass spectrometry workflows.