Analysis of Terpenes in Cannabis Using Agilent HSS-GC-MSD with FID

Cannabis products have been promoted as natural remedies, giving rise to a wide range of CBD oils, creams, pills, and gummies available in stores and online marketplaces across the U.S. If you’ve ever examined a bottle of CBD oil, you may have noticed "terpenes" listed as an ingredient.

Terpenes are the compounds responsible for the distinct aroma and flavor of different marijuana strains. While the medical benefits of terpenes are still under research, as noted by Chemical and Engineering News, these naturally occurring aromatic compounds are believed to enhance the therapeutic effects of hemp and marijuana plants.

In August of 2019, The Drug Enforcement Administration announced that they would be expanding the medical research for marijuana in the United States. As the understanding of how terpenes interact in cannabis products and their effects on the end user grows, so too does the need for analysis of residual solvents and terpenes.

Terpenes are naturally occurring volatile isoprenes, which allow for headspace analysis. Agilent scientists are able to rapidly and robustly analyze 22 terpenes in just over five minutes using an Agilent headspace-gas chromatography-mass selective detection (HSS-GC-MSD) system with concomitant flame ionization detector (FID)

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