Agilent HPLC Columns

ZORBAX, Poroshell, Polaris & Pursuit HPLC Columns

Chrom Tech supplies a complete portfolio of Agilent HPLC columns for small-molecule analysis, including superficially porous InfinityLab Poroshell 120 columns and fully porous ZORBAX, Polaris, and Pursuit series. Together, these families support an exceptionally wide range of separation modes, selectivity options, and analytical workflows.

Reversed-phase LC remains the dominant technique for small-molecule separations, and choosing the right phase is critical for achieving consistent retention, resolution, and peak shape. Agilent’s column platforms deliver industry-leading reproducibility and efficiency, with multiple bonded phases, pore sizes, and particle technologies engineered for both HPLC and UHPLC performance.

For expert guidance in selecting the ideal Agilent column for your application, contact Chrom Tech to connect with our chromatography specialists.

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SKU Name LC Column Phase Particle Size Inner Diameter (ID) Length
SKU
823750-902
Name
823750-902 - UHPLC Grd, SB-C18,3.0mm, 1.8um,3pk
LC Column Phase
SB-C18
Particle Size
1.8 um
Inner Diameter (ID)
3 mm
Length
5 mm
SKU
822975-932
Name
822975-932 - SB-C18 4.6x50mm 1.8um 3PK
LC Column Phase
SB-C18
Particle Size
1.8 um
Inner Diameter (ID)
4.6 mm
Length
50 mm
SKU
832975-902
Name
832975-902 - SB-C18,4.6x20mm,3.5um,600 bar,Col
LC Column Phase
SB-C18
Particle Size
3.5 um
Inner Diameter (ID)
4.6 mm
Length
20 mm
SKU
822975-902
Name
822975-902 - SB-C18 4.6x50mm 1.8um
LC Column Phase
SB-C18
Particle Size
1.8 um
Inner Diameter (ID)
4.6 mm
Length
50 mm
SKU
822700-932
Name
822700-932 - SB-C18 2.1x50mm 1.8um 3PK
LC Column Phase
SB-C18
Particle Size
1.8 um
Inner Diameter (ID)
2.1 mm
Length
50 mm
SKU
827975-902
Name
827975-902 - SB-C18 4.6 X 50 mm
LC Column Phase
SB-C18
Particle Size
1.8 um
Inner Diameter (ID)
4.6 mm
Length
50 mm
SKU
820950-936
Name
820950-936 - Eclipse Plus C18 Grd,4.6x12.5mm,5um,4pk
LC Column Phase
Eclipse Plus C18
Particle Size
5 um
Inner Diameter (ID)
4.6 mm
Length
13 mm
SKU
821725-916
Name
821725-916 - Poroshell 120 guard column
LC Column Phase
EC-C18
Particle Size
4 um
Inner Diameter (ID)
2.1 mm
Length
5 mm
SKU
830990-902
Name
830990-902 - ZORBAX SB-C18,2.1x150mm,3.5um
LC Column Phase
SB-C18
Particle Size
3.5 um
Inner Diameter (ID)
2.1 mm
Length
150 mm
SKU
827975-302
Name
827975-302 - SB-C18 3.0 x 50 mm
LC Column Phase
SB-C18
Particle Size
1.8 um
Inner Diameter (ID)
3 mm
Length
50 mm
SKU
820950-930
Name
820950-930 - Extend-C18, Guard, 5u, 4.6x12.5mm 4PK
LC Column Phase
Extend-C18
Particle Size
5 um
Inner Diameter (ID)
4.6 mm
Length
13 mm
SKU
821725-912
Name
821725-912 - Poroshell 120, UHPLC Guards, SB-C18,2.1mm,3pk
LC Column Phase
SB-C18
Particle Size
2.7 um
Inner Diameter (ID)
2.1 mm
Length
5 mm
Key Definitions ▸
Reversed-Phase Chromatography (RP)
The most widely used LC mode. Utilizes non-polar stationary phases such as C18 or C8 and polar mobile phases. Ideal for small molecules requiring predictable retention and high reproducibility.
Superficially Porous Particles (SPP)
Also called “core-shell” particles. Used in Agilent Poroshell 120 columns to deliver UHPLC-grade efficiency with reduced back-pressure, enabling faster and higher-resolution separations.
Fully Porous Particles (FPP)
Traditional particle design used in Agilent ZORBAX, Polaris, and Pursuit columns. Offers broad selectivity, robust durability, and compatibility across classic and modern LC methods.
Particle Size
A key factor influencing efficiency, pressure, and resolution. Smaller particles (≤2–3 µm) deliver UHPLC-level performance, while 3.5–5 µm particles are ideal for standard HPLC systems.
Stationary Phase
The bonded surface chemistry—such as C18, C8, Phenyl-Hexyl, CN, or Bonus-RP—that determines retention, selectivity, and overall chromatographic behavior.
Frequently Asked Questions ▸
What types of Agilent HPLC columns does Chrom Tech offer?
Chrom Tech offers the full Agilent portfolio, including InfinityLab Poroshell 120, ZORBAX Eclipse Plus and XDB, StableBond, Extend-C18, Bonus-RP, Polaris, and Pursuit XRs columns—optimized for small-molecule separations.
What is the difference between Poroshell and ZORBAX columns?
Poroshell 120 columns use superficially porous particles for higher efficiency and faster separations, while ZORBAX columns are fully porous and offer broad selectivity across many stationary phases and applications.
Can these Agilent columns be used for UHPLC?
Yes. Many Agilent columns—including Poroshell 120, ZORBAX Eclipse Plus, and Pursuit XRs—are rated for UHPLC platforms and deliver high efficiency and excellent resolution at elevated pressures.