Agilent HPLC Columns

ZORBAX, Poroshell, Polaris & Pursuit HPLC Columns

Chrom Tech supplies a complete portfolio of Agilent HPLC columns for small-molecule analysis, including superficially porous InfinityLab Poroshell 120 columns and fully porous ZORBAX, Polaris, and Pursuit series. Together, these families support an exceptionally wide range of separation modes, selectivity options, and analytical workflows.

Reversed-phase LC remains the dominant technique for small-molecule separations, and choosing the right phase is critical for achieving consistent retention, resolution, and peak shape. Agilent’s column platforms deliver industry-leading reproducibility and efficiency, with multiple bonded phases, pore sizes, and particle technologies engineered for both HPLC and UHPLC performance.

For expert guidance in selecting the ideal Agilent column for your application, contact Chrom Tech to connect with our chromatography specialists.

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SKU Name LC Column Phase Particle Size Inner Diameter (ID) Length
SKU
681975-302T
Name
681975-302T - Poroshell 120 SB-C18, 3X30 mm, 2.7 u
LC Column Phase
SB-C18
Particle Size
2.7 um
Inner Diameter (ID)
3 mm
Length
30 mm
SKU
690970-901T
Name
690970-901T - Poroshell 120 HILIC, 4.6X250 mm, 4 um, with Column ID
LC Column Phase
HILIC
Particle Size
4 um
Inner Diameter (ID)
4.6 mm
Length
250 mm
SKU
681775-902T
Name
681775-902T - Poroshell 120 SB-C18, 2.1X30 mm, 2.7 um, with Column ID
LC Column Phase
SB-C18
Particle Size
2.7 um
Inner Diameter (ID)
2.1 mm
Length
30 mm
SKU
693970-901T
Name
693970-901T - Poroshell 120 HILIC, 4.6X150 mm, 4 um, with Column ID
LC Column Phase
HILIC
Particle Size
4 um
Inner Diameter (ID)
4.6 mm
Length
150 mm
SKU
650750-901T
Name
650750-901T - Poroshell 120 HILIC, 2.1X250 mm, 4 um, with Column ID
LC Column Phase
HILIC
Particle Size
4 um
Inner Diameter (ID)
2.1 mm
Length
250 mm
SKU
690970-301T
Name
690970-301T - Poroshell 120 HILIC, 3X250 mm, 4 um, with Column ID
LC Column Phase
HILIC
Particle Size
4 um
Inner Diameter (ID)
3 mm
Length
250 mm
SKU
A2005MG2
Name
A2005MG2 - MetaGuard 2.0mm Polaris Si-A 3u
LC Column Phase
Si-A
Particle Size
3 um
Inner Diameter (ID)
2 mm
Length
SKU
A2005MG
Name
A2005MG - MetaGuard 4.6mm Polaris Si-A 3u
LC Column Phase
Si-A
Particle Size
3 um
Inner Diameter (ID)
4.6 mm
Length
SKU
A2004250X212
Name
A2004250X212 - Polaris Si-A 10u 250 x 21.2mm
LC Column Phase
Si-A
Particle Size
10 um
Inner Diameter (ID)
21.2 mm
Length
250 mm
SKU
A2003250X212
Name
A2003250X212 - Polaris Si-A 5u 250 x 21.2mm
LC Column Phase
Si-A
Particle Size
5 um
Inner Diameter (ID)
21.2 mm
Length
250 mm
SKU
959961-918
Name
959961-918 - Eclipse PAH, 4.6x100mm,3.5um
LC Column Phase
Eclipse PAH
Particle Size
3.5 um
Inner Diameter (ID)
4.6 mm
Length
100 mm
SKU
959961-901
Name
959961-901 - ZORBAX HILIC Plus, 4.6x100mm, 3.5um
LC Column Phase
HILIC Plus
Particle Size
3.5 um
Inner Diameter (ID)
4.6 mm
Length
100 mm
Key Definitions ▸
Reversed-Phase Chromatography (RP)
The most widely used LC mode. Utilizes non-polar stationary phases such as C18 or C8 and polar mobile phases. Ideal for small molecules requiring predictable retention and high reproducibility.
Superficially Porous Particles (SPP)
Also called “core-shell” particles. Used in Agilent Poroshell 120 columns to deliver UHPLC-grade efficiency with reduced back-pressure, enabling faster and higher-resolution separations.
Fully Porous Particles (FPP)
Traditional particle design used in Agilent ZORBAX, Polaris, and Pursuit columns. Offers broad selectivity, robust durability, and compatibility across classic and modern LC methods.
Particle Size
A key factor influencing efficiency, pressure, and resolution. Smaller particles (≤2–3 µm) deliver UHPLC-level performance, while 3.5–5 µm particles are ideal for standard HPLC systems.
Stationary Phase
The bonded surface chemistry—such as C18, C8, Phenyl-Hexyl, CN, or Bonus-RP—that determines retention, selectivity, and overall chromatographic behavior.
Frequently Asked Questions ▸
What types of Agilent HPLC columns does Chrom Tech offer?
Chrom Tech offers the full Agilent portfolio, including InfinityLab Poroshell 120, ZORBAX Eclipse Plus and XDB, StableBond, Extend-C18, Bonus-RP, Polaris, and Pursuit XRs columns—optimized for small-molecule separations.
What is the difference between Poroshell and ZORBAX columns?
Poroshell 120 columns use superficially porous particles for higher efficiency and faster separations, while ZORBAX columns are fully porous and offer broad selectivity across many stationary phases and applications.
Can these Agilent columns be used for UHPLC?
Yes. Many Agilent columns—including Poroshell 120, ZORBAX Eclipse Plus, and Pursuit XRs—are rated for UHPLC platforms and deliver high efficiency and excellent resolution at elevated pressures.