Ion Mixed Mode Silica SPE

Agilent Bond Elut Ion Multi Mode Silica SPE

For more than 30 years, Agilent Bond Elut has been recognized as the industry benchmark in solid phase extraction (SPE). Trusted by analytical chemists worldwide, Bond Elut products are extensively cited in scientific literature for their reliability, reproducibility, and versatility across a range of analytical applications.

Every Bond Elut cartridge is produced using state-of-the-art automated manufacturing processes to ensure the highest levels of consistency and quality. Each unit undergoes up to 25 quality assurance tests during production to verify reproducibility and performance. If any deviation is detected, the cartridge is automatically removed from the production line, guaranteeing exceptional reliability in every lot.

With over 40 unique sorbent chemistries available in formats including straight barrel, large reservoir capacity (LRC), and Bond Elut Junior (Jr), Agilent’s SPE portfolio offers solutions for nearly every type of sample and workflow. The Bond Elut Ion Multi Mode Silica SPE family combines the selectivity of ion exchange with the versatility of reversed-phase interactions, enabling efficient extraction of acidic, basic, and neutral compounds from complex biological matrices.

Bond Elut AccuCAT

• SCX and SAX mixed functionalities provide broad analyte extraction capability
• Ultra-clean mixed sorbent bed ensures reproducible, high-purity extractions

Bond Elut AccuCAT cartridges combine strong cation exchange (SCX) and strong anion exchange (SAX) sorbents in a single mixed bed, enabling simultaneous extraction of acidic, basic, and neutral analytes. They are particularly effective for isolating catecholamines and other bioactive compounds from urine and biological fluids with minimal sample preparation steps.

Bond Elut Certify

• Mixed-mode phase combining C8 and SCX sorbents
• Ideal for extraction of basic (cationic) drugs from urine and blood

Bond Elut Certify cartridges feature a dual-phase composition of nonpolar C8 and strong cation exchange (SCX) sorbents. This mixed-mode configuration enables efficient isolation of basic compounds from biological matrices such as urine, plasma, and serum. It is widely used in forensic and clinical toxicology applications for reliable drug screening and quantitation.

Bond Elut Certify II

• Mixed-mode phase combining C8 and SAX sorbents
• Optimized for acidic drug extraction from urine and blood

Bond Elut Certify II cartridges were developed for rapid and selective extraction of acidic drugs and metabolites from biological samples. Featuring a mixed-mode combination of nonpolar C8 and strong anion exchange (SAX) sorbents, Certify II provides exceptional retention and recovery of compounds such as 11-nor-Δ9-tetrahydrocannabinol-carboxylic acid (THC-COOH), salicylic acid, ibuprofen, acetaminophen, and other analytes with both hydrophobic and anionic properties.